UNSPECIFIED (1999) Separations of chiral aryl alcohol derivatives on the (+)- and (-)-hexahelicen-7-yl acetic acid bonded phases. CHIRALITY, 11 (5-6). pp. 416-419. ISSN 0899-0042

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Abstract

This paper describes the synthesis of (+)- and (-)-hexahelicen-7 yl acetic acid bonded phases using two bonding reagents. The relationship between the structure of a series of DNB derivatives of chiral aryl alcohols and their enantioselectivity on the (+)-hexahelicen-7-yl acetic acid bonded phase is presented. The DNB derivatives were selected to reflect a range of alkyl side chain lengths, spacer chain lengths between the chiral centre, and the aromatic group and the aromatic group size. The resolution increases with increasing length of the alkyl chain at the chiral centre and decreases on increasing the distance between the aromatic group and the chiral centre. It was confirmed that the enantiomer elution order reverses when changing from the (+)- to the (-)-hexahelicene phase. Chirality 11:416-419, 1999. (C) 1999 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	CHIRALITY
Publisher:	WILEY-LISS
ISSN:	0899-0042
Date:	1999
Volume:	11
Number:	5-6
Number of Pages:	4
Page Range:	pp. 416-419
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14493

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