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MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis
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Zhou, Shanshan, Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2020) MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis. Chemical Communications, 56 (92). pp. 14443-14446. doi:10.1039/d0cc05658h
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WRAP-MmfL-catalyses-formation-phosphorylated-methylenomycin-fuan-biosynthesis-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (1825Kb) | Preview |
Official URL: https://doi.org/10.1039/D0CC05658H
Abstract
Using a combination of a synthetic substrate analogue and product standard, MmfL, a homologue of the γ-butyrolactone biosynthetic enzyme AfsA, was shown to catalyse the condensation of dihydroxyacetone phosphate with a β-ketoacyl thioester to form a phosphorylated butenolide intermediate in the biosynthesis of the methylenomycin furans, which induce methlenomycin antibiotic production in Streptomyces coelicolor A3(2). AfsA homologues are also involved in the biosynthesis of 2-akyl-4-hydroxy-3-methyl butenolide inducers of antibiotic production in other Streptomyces species, indicating that diverse signalling molecules are assembled from analogous phosphorylated butenolide intermediates.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Furans -- Synthesis, Biosynthesis, Streptomyces coelicolor | ||||||||||||||||||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||||||||||||||||||
| Publisher: | Royal Society of Chemistry (RSC) | ||||||||||||||||||||||||
| ISSN: | 1364-548X | ||||||||||||||||||||||||
| Official Date: | 22 October 2020 | ||||||||||||||||||||||||
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| Volume: | 56 | ||||||||||||||||||||||||
| Number: | 92 | ||||||||||||||||||||||||
| Page Range: | pp. 14443-14446 | ||||||||||||||||||||||||
| DOI: | 10.1039/d0cc05658h | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | http://creativecommons.org/licenses/by-nc/3.0/ | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||||||||||||||
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