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MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis
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Zhou, Shanshan, Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2020) MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis. Chemical Communications, 56 (92). pp. 14443-14446. doi:10.1039/d0cc05658h ISSN 1364-548X.
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WRAP-MmfL-catalyses-formation-phosphorylated-methylenomycin-fuan-biosynthesis-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (1825Kb) | Preview |
Official URL: https://doi.org/10.1039/D0CC05658H
Abstract
Using a combination of a synthetic substrate analogue and product standard, MmfL, a homologue of the γ-butyrolactone biosynthetic enzyme AfsA, was shown to catalyse the condensation of dihydroxyacetone phosphate with a β-ketoacyl thioester to form a phosphorylated butenolide intermediate in the biosynthesis of the methylenomycin furans, which induce methlenomycin antibiotic production in Streptomyces coelicolor A3(2). AfsA homologues are also involved in the biosynthesis of 2-akyl-4-hydroxy-3-methyl butenolide inducers of antibiotic production in other Streptomyces species, indicating that diverse signalling molecules are assembled from analogous phosphorylated butenolide intermediates.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Furans -- Synthesis, Biosynthesis, Streptomyces coelicolor | ||||||||||||||||||||||||
Journal or Publication Title: | Chemical Communications | ||||||||||||||||||||||||
Publisher: | Royal Society of Chemistry (RSC) | ||||||||||||||||||||||||
ISSN: | 1364-548X | ||||||||||||||||||||||||
Official Date: | 22 October 2020 | ||||||||||||||||||||||||
Dates: |
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Volume: | 56 | ||||||||||||||||||||||||
Number: | 92 | ||||||||||||||||||||||||
Page Range: | pp. 14443-14446 | ||||||||||||||||||||||||
DOI: | 10.1039/d0cc05658h | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | http://creativecommons.org/licenses/by-nc/3.0/ | ||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
Date of first compliant deposit: | 8 December 2020 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 9 December 2020 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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