UNSPECIFIED (1999) Expression pattern of a novel hyaluronidase during Xenopus embryogenesis. MECHANISMS OF DEVELOPMENT, 82 (1-2). pp. 213-217. ISSN 0925-4773

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Abstract

We have isolated a cDNA encoding a novel hyaluronidase, which is expressed during embryogenesis. The encoded protein was expressed as a fusion polypeptide with glutathione S-transferase, and the affinity-purified fusion protein was shown to posses hyaluronidase activity with a pH optimum about pH 4.0. The expression of the XEH1 gene was analysed by in situ hybridization, and was first apparent in scattered cells in a broad ventral region of late gastrula embryos. As development proceeded through to tailbud stages, the domain of expression became progressively more restricted, eventually being located in the developing liver rudiment near the primary hepatic cavity. The results reveal the dynamic regulation of the contrasting activities of hyaluronan synthesis and degradation during early morphogenetic movements. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	MECHANISMS OF DEVELOPMENT
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0925-4773
Date:	April 1999
Volume:	82
Number:	1-2
Number of Pages:	5
Page Range:	pp. 213-217
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14509

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