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Electrostatic-responsive microdroplet lasers for ultrasensitive molecular detection

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Wang, Ziyihui, Zhang, Yifan, Xu, Tianhua, Yuan, Zhiyi, Ding, Jiazheng, Chen, Yu-Cheng and Tiegen, Liu (2020) Electrostatic-responsive microdroplet lasers for ultrasensitive molecular detection. In: SPIE/COS Photonics Asia, Online, 11-16 Oct. Published in: Proceedings of SPIE - International Society for Optical Engineering, 11554 ISSN 0277-786X. doi:10.1117/12.2574262

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Official URL: https://doi.org/10.1117/12.2574262

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Abstract

Electrostatics plays a critical function in most biomolecules, therefore monitoring subtle biomolecular bindings and dynamics via the electrostatic changes of biomolecules at biointerfaces has been an attractive topic recently and has provided the basis in diagnosis and biomedical science. Here we present a bioelectrostatic responsive microlaser based on liquid crystal (LC) droplet and explored its application for ultrasensitive detection of negatively charged biomolecules. Whispering gallery mode (WGM) lasing from positively charged LC microdroplets was applied as the optical resonator, where the lasing wavelength shift was employed as a sensing parameter. With the dual impacts from whispering-gallery mode and liquid crystal, molecular binding signals will be amplified in such LC droplet sensors. It is found that molecular electrostatic changes at the biointerface of droplet triggered wavelength shift in lasing spectra. The total wavelength shift increased proportionally with the adhering target concentrations. Compared to a conventional polarized optical microscope, significant improvements in sensitivity and dynamic range by four orders of magnitude were achieved. Our work indicated that the surface-to-volume ratio plays a critical role in the detection sensitivity in WGM laser-based microsensors. Finally, bovine serum albumin and specific biosensing using streptavidin and biotin were exploited to demonstrate the potential applications of microlasers with a detection limit on the order of 1 pM. We anticipate this approach will open new possibilities for the ultrasensitive label-free detection of charged biomolecules and molecular interactions by providing a lower detection limit than conventional methods.

Item Type: Conference Item (Paper)
Subjects: Q Science > QC Physics
Q Science > QP Physiology
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TS Manufactures
Divisions: Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH): Liquid crystals , Liquid crystal devices, Biological interfaces, Electrostatics, Biomolecules
Series Name: Advanced Sensor Systems and Applications X
Journal or Publication Title: Proceedings of SPIE - International Society for Optical Engineering
Publisher: S P I E - International Society for Optical Engineering
ISSN: 0277-786X
Book Title: Semiconductor Lasers and Applications X
Official Date: 2020
Dates:
DateEvent
2020Published
10 October 2020Available
10 October 2020Accepted
Volume: 11554
Article Number: 1155406
DOI: 10.1117/12.2574262
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: Copyright © 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
SUG 4082308.040 National Taipei University of Technologyhttp://dx.doi.org/10.13039/501100006705
2020XY-0033Tianjin University of Science and Technologyhttp://dx.doi.org/10.13039/501100004712
Conference Paper Type: Paper
Title of Event: SPIE/COS Photonics Asia
Type of Event: Conference
Location of Event: Online
Date(s) of Event: 11-16 Oct
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