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Engineering bacteria to produce pure phage-like particles for gene delivery

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Tridgett, Matthew, Ababi, Maria, Osgerby, Alexander, Ramirez Garcia, Robert and Jaramillo, Alfonso (2021) Engineering bacteria to produce pure phage-like particles for gene delivery. ACS Synthetic Biology, 10 (1). pp. 107-114. doi:10.1021/acssynbio.0c00467

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Official URL: https://doi.org/10.1021/acssynbio.0c00467

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Abstract

Natural and engineered phages have been used in many applications, but their use to deliver user-defined genetic cargoes has been hampered by contamination with replicative phage, restricting use of the technology beyond the laboratory. Here we present a method to produce transducing particles without contamination. In addition, we demonstrate the use of a helper phage-free transducing particle preparation as an antimicrobial agent. This will pave the way for the development of new phage-based technologies with greater scope than lytic phage therapy.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: ACS Synthetic Biology
Publisher: American Chemical Society
ISSN: 2161-5063
Official Date: 15 January 2021
Dates:
DateEvent
15 January 2021Published
14 December 2020Available
24 November 2020Accepted
Date of first compliant deposit: 4 December 2020
Volume: 10
Number: 1
Page Range: pp. 107-114
DOI: 10.1021/acssynbio.0c00467
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Description:
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/P020615/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M01116X/1Midlands Integrative Biosciences Training Partnership (MIBTP)UNSPECIFIED
1936220Medical Research Council Doctoral Training Partnership in Interdisciplinary Biomedical Research (MRC DTP IBR)UNSPECIFIED
BB/M017982/1Warwick Integrative Synthetic Biology centre (WISB)UNSPECIFIED
UNSPECIFIEDWarwick-Monash AllianceUNSPECIFIED
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