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Mitogen and stress-activated protein kinase 1 negatively regulates hippocampal neurogenesis
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Olateju, Oladiran, Morè, Lorenzo, Arthur, J. Simon C. and Frenguelli, Bruno G. (2021) Mitogen and stress-activated protein kinase 1 negatively regulates hippocampal neurogenesis. Neuroscience, 452 . pp. 228-234. doi:10.1016/j.neuroscience.2020.11.017 ISSN 0306-4522.
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WRAP-Mitogen-stress-activated-protein-kinase-1-negatively-neurogenesis-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1114Kb) | Preview |
Official URL: https://doi.org/10.1016/j.neuroscience.2020.11.017
Abstract
Neurogenesis in the subgranular zone (SGZ) of the adult hippocampus can be stimulated by a variety of means, including via exposure of experimental animals to an enriched environment that provides additional sensory, social, and motor stimulation. Tangible health and cognitive benefits accrue in enriched animals, including the amelioration of signs modelling psychiatric, neurological and neurodegenerative conditions that affect humans, which may in part be due to enhanced production of neurons. A key factor in the neuronal response to enrichment is the release of brain-derived neurotrophic factor (BDNF) and the activation of the Mitogen-Activated Protein Kinase (MAPK) cascade, which can lead to the stimulation of neurogenesis. Mitogen- and Stress-Activated protein Kinase 1 (MSK1) is a nuclear enzyme downstream of BDNF and MAPK that regulates transcription. MSK1 has previously been implicated in both basal and stimulated neurogenesis on the basis of studies with mice lacking MSK1 protein. In the present study, using mice in which only the kinase activity of MSK1 is lacking, we show that the rate of cellular proliferation in the SGZ (Ki-67 staining) is unaffected by the MSK1 kinase-dead (KD) mutation, and no different from controls levels after five weeks of enrichment. However, compared to wild-type mice, the number of doublecortin (DCX)-positive cells was greater in both standard-housed and enriched MSK1 KD mice. These observations suggest that, while MSK1 does not influence the basal rate of proliferation of neuronal precursors, MSK1 negatively regulates the number of cells destined to become neurons, potentially as a homeostatic control on the number of new neurons integrating into the dentate gyrus. [Abstract copyright: Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.]
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Developmental neurobiology, Neurotrophic functions -- Research, Mitogen-activated protein kinases, Hippocampus (Brain) | ||||||||
| Journal or Publication Title: | Neuroscience | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 0306-4522 | ||||||||
| Official Date: | 1 January 2021 | ||||||||
| Dates: |
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| Volume: | 452 | ||||||||
| Page Range: | pp. 228-234 | ||||||||
| DOI: | 10.1016/j.neuroscience.2020.11.017 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router ** History: received 01-08-2020; revised 20-10-2020; accepted 10-11-2020. | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 6 January 2021 | ||||||||
| Date of first compliant Open Access: | 7 January 2021 | ||||||||
| RIOXX Funder/Project Grant: |
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