Tandem cyclisations of amidyl radicals derived from O-acyl hydroxamic acid derivatives
UNSPECIFIED. (1999) Tandem cyclisations of amidyl radicals derived from O-acyl hydroxamic acid derivatives. SYNLETT (4). pp. 441-443. ISSN 0936-5214Full text not available from this repository.
Amidyl radicals generated from tributylstannane mediated homolysis of O-acyl hydroxamic acid derivatives 5a-b undergo tandem cyclisations to give pyrrolizidinones 6a-c and indolizidinones 7a-b respectively while 5c-d undergo monocyclisation to give beta-lactam 10a and gamma-lactam 11a respectively. On the other hand the reaction of 5d-f with Cu(OTf)(2)/DBN furnishes mixtures of reduction 10b, monocyclisation 10a and tandem cyclisation 9 products with the: ratio dependant upon the nature of the O-acyl group and the solvent and concentration employed.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||SYNLETT|
|Publisher:||GEORG THIEME VERLAG|
|Number of Pages:||3|
|Page Range:||pp. 441-443|
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