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Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica

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Chhun, Audam, Sousoni, Despoina, Aguilo-Ferretjans, Maria del Mar, Song, Lijiang, Corre, Christophe and Christie-Oleza, Joseph A. (2021) Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica. Microbial Biotechnology, 14 (1). pp. 291-306. doi:10.1111/1751-7915.13722

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Official URL: https://doi.org/10.1111/1751-7915.13722

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Abstract

Filamentous members of the phylum Actinobacteria are a remarkable source of natural products with pharmaceutical potential. The discovery of novel molecules from these organisms is, however, hindered because most of the biosynthetic gene clusters (BGCs) encoding these secondary metabolites are cryptic or silent and are referred to as orphan BGCs. While co‐culture has proven to be a promising approach to unlock the biosynthetic potential of many microorganisms by activating the expression of these orphan BGCs, it still remains an underexplored technique. The marine actinobacterium Salinispora tropica, for instance, produces valuable compounds such as the anti‐cancer molecule salinosporamide but half of its putative BGCs are still orphan. Although previous studies have used marine heterotrophs to induce orphan BGCs in Salinispora, its co‐culture with marine phototrophs has yet to be investigated. Following the observation of an antimicrobial activity against a range of phytoplankton by S. tropica, we here report that the photosynthate released by photosynthetic primary producers influences its biosynthetic capacities with production of cryptic molecules and the activation of orphan BGCs. Our work, using an approach combining metabolomics and proteomics, pioneers the use of phototrophs as a promising strategy to accelerate the discovery of novel natural products from marine actinobacteria.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QK Botany
Divisions: Faculty of Science > Chemistry
Faculty of Science > Life Sciences (2010- )
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Phytoplankton, Primary productivity (Biology) , Marine productivity, Marine metabolites, Actinobacteria
Journal or Publication Title: Microbial Biotechnology
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 1751-7907
Official Date: January 2021
Dates:
DateEvent
January 2021Published
5 December 2020Available
14 November 2020Accepted
Volume: 14
Number: 1
Page Range: pp. 291-306
DOI: 10.1111/1751-7915.13722
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/M01116X/1 ( MIBTP PhD)[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
NE/L002493/1[NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
NE/K009044/1 [NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
RYC-2017-22452 ( Ramon y Cajal)Ministerio de Ciencia e Innovaciónhttp://dx.doi.org/10.13039/501100004837
RYC-2017-22452 ( Ramon y Cajal)Agenzia Nazionale di Valutazione del Sistema Universitario e della RicercaUNSPECIFIED
RYC-2017-22452 ( Ramon y Cajal)European Social Fundhttp://dx.doi.org/10.13039/501100004895
BB/ M022765/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
765147Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
BB/ M017982/1 [BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/R000689/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
EP/P0305721/1[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266

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