UNSPECIFIED (1999) GenTHREADER: An efficient and reliable protein fold recognition method for genomic sequences. Journal of Molecular Biology, 287 (4). pp. 797-815. ISSN 0022-2836

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Abstract

A new protein fold recognition method is described which is both fast and reliable. The method uses a traditional sequence alignment algorithm to generate alignments which are then evaluated by a method derived from threading techniques. As a final step, each threaded model is evaluated by a neural network in order to produce a single measure of confidence in the proposed prediction. The speed of the method, along with its sensitivity and very low false-positive rate makes it ideal for automatically predicting the structure of all the proteins in a translated bacterial genome (proteome). The method has been applied to the genome of Mycoplasma genitalium, and analysis of the results shows that as many as 46% of the proteins derived from the predicted protein coding regions have a significant relationship to a protein of known structure. Ln some cases, however, only one domain of the protein can be predicted, giving a total coverage of 30 % when calculated as a fraction of the number of amino acid residues in the whole proteome. (C) 1999 Academic Press.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	Journal of Molecular Biology
Publisher:	ACADEMIC PRESS LTD
ISSN:	0022-2836
Date:	9 April 1999
Volume:	287
Number:	4
Number of Pages:	19
Page Range:	pp. 797-815
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14626

Data sourced from Thomson Reuters' Web of Knowledge

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