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Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes
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Gharanei, Seley, Fishwick, Katherine, Peter Durairaj, Ruban Rex, Jin, Tianrong, Siamantouras, Eleftherios, Liu, Kuo-Kang, Straube, Anne, Lucas, Emma S., Weston, Christopher, Rantakari, Pia, Salmi, Marko, Jalkanen, Sirpa, Brosens, Jan J. and Tan, Bee K. (2021) Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes. Frontiers in Cell and Developmental Biology, 8 . 621016. doi:10.3389/fcell.2020.621016 ISSN 2296-634X.
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Official URL: http://dx.doi.org/10.3389/fcell.2020.621016
Abstract
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule and a primary amine oxidase involved in immune cell trafficking. Leukocyte extravasation into tissues is mediated by adhesion molecules expressed on endothelial cells and pericytes. Pericytes play a major role in the angiogenesis and vascularization of cycling endometrium. However, the functional properties of pericytes in the human endometrium are not known. Here we show that pericytes surrounding the spiral arterioles in midluteal human endometrium constitutively express VAP-1. We first characterize these pericytes and demonstrate that knockdown of VAP-1 perturbed their biophysical properties and compromised their contractile, migratory, adhesive and clonogenic capacities. Furthermore, we show that loss of VAP-1 disrupts pericyte-uterine natural killer cell interactions in vitro. Taken together, the data not only reveal that endometrial pericytes represent a cell population with distinct biophysical and functional properties but also suggest a pivotal role for VAP-1 in regulating the recruitment of innate immune cells in human endometrium. We posit that VAP-1 could serve as a potential biomarker for pregnancy pathologies caused by a compromised perivascular environment prior to conception.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology R Medicine > RD Surgery R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Adhesions, Endothelial cells, Leucocytes, Pregnancy, Mesenchymal stem cells | |||||||||||||||||||||
| Journal or Publication Title: | Frontiers in Cell and Developmental Biology | |||||||||||||||||||||
| Publisher: | Frontiers Media | |||||||||||||||||||||
| ISSN: | 2296-634X | |||||||||||||||||||||
| Official Date: | 18 January 2021 | |||||||||||||||||||||
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| Volume: | 8 | |||||||||||||||||||||
| Article Number: | 621016 | |||||||||||||||||||||
| DOI: | 10.3389/fcell.2020.621016 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
| Date of first compliant deposit: | 22 December 2020 | |||||||||||||||||||||
| Date of first compliant Open Access: | 18 January 2021 | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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