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Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes

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Gharanei, Seley, Fishwick, Katherine, Peter Durairaj, Ruban Rex, Jin, Tianrong, Siamantouras, Eleftherios, Liu, Kuo-Kang, Straube, Anne, Lucas, Emma S., Weston, Christopher, Rantakari, Pia, Salmi, Marko, Jalkanen, Sirpa, Brosens, Jan J. and Tan, Bee K. (2021) Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes. Frontiers in Cell and Developmental Biology, 8 . 621016. doi:10.3389/fcell.2020.621016

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Official URL: http://dx.doi.org/10.3389/fcell.2020.621016

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Abstract

Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule and a primary amine oxidase involved in immune cell trafficking. Leukocyte extravasation into tissues is mediated by adhesion molecules expressed on endothelial cells and pericytes. Pericytes play a major role in the angiogenesis and vascularization of cycling endometrium. However, the functional properties of pericytes in the human endometrium are not known. Here we show that pericytes surrounding the spiral arterioles in midluteal human endometrium constitutively express VAP-1. We first characterize these pericytes and demonstrate that knockdown of VAP-1 perturbed their biophysical properties and compromised their contractile, migratory, adhesive and clonogenic capacities. Furthermore, we show that loss of VAP-1 disrupts pericyte-uterine natural killer cell interactions in vitro. Taken together, the data not only reveal that endometrial pericytes represent a cell population with distinct biophysical and functional properties but also suggest a pivotal role for VAP-1 in regulating the recruitment of innate immune cells in human endometrium. We posit that VAP-1 could serve as a potential biomarker for pregnancy pathologies caused by a compromised perivascular environment prior to conception.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
R Medicine > RD Surgery
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Science > Engineering
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Adhesions, Endothelial cells, Leucocytes, Pregnancy, Mesenchymal stem cells
Journal or Publication Title: Frontiers in Cell and Developmental Biology
Publisher: Frontiers Media
ISSN: 2296-634X
Official Date: 18 January 2021
Dates:
DateEvent
18 January 2021Published
16 December 2020Accepted
Date of first compliant deposit: 22 December 2020
Volume: 8
Article Number: 621016
DOI: 10.3389/fcell.2020.621016
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDTommy'shttp://dx.doi.org/10.13039/501100009324
212233/Z/18/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
UNSPECIFIEDWarwick Medical Schoolhttp://dx.doi.org/10.13039/501100004443
200870/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
MR/P013538/2[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/R020981/2[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
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