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Rapid rule-based reward reversal and the lateral orbitofrontal cortex
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Rolls, Edmund T., Vatansever, Deniz, Li, Yuzhu, Cheng, Wei and Feng, Jianfeng (2020) Rapid rule-based reward reversal and the lateral orbitofrontal cortex. Cerebral Cortex Communications, 1 (1). tgaa087. doi:10.1093/texcom/tgaa087 ISSN 2632-7376.
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WRAP-rapid-rule-based-reward-reversal-lateral-orbitofrontal-cortex-Rolls-2020.pdf - Published Version - Requires a PDF viewer. Download (1493Kb) | Preview |
Official URL: http://dx.doi.org/10.1093/texcom/tgaa087
Abstract
Humans and other primates can reverse their choice of stimuli in one trial when the rewards delivered by the stimuli change or reverse. Rapidly changing our behavior when the rewards change is important for many types of behavior, including emotional and social behavior. It is shown in a one-trial rule-based Go-NoGo deterministic visual discrimination reversal task to obtain points, that the human right lateral orbitofrontal cortex and adjoining inferior frontal gyrus is activated on reversal trials, when an expected reward is not obtained, and the non-reward allows the human to switch choices based on a rule. This reward reversal goes beyond model-free reinforcement learning. This functionality of the right lateral orbitofrontal cortex shown here in very rapid, one-trial, rule-based changes in human behavior when a reward is not received is related to the emotional and social changes that follow orbitofrontal cortex damage, and to depression in which this non-reward system is oversensitive and over-connected.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Prefrontal cortex, Computational neuroscience , Cerebral cortex, Depression, Mental , Emotions | |||||||||||||||||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex Communications | |||||||||||||||||||||||||||||||||
Publisher: | Oxford University Press | |||||||||||||||||||||||||||||||||
ISSN: | 2632-7376 | |||||||||||||||||||||||||||||||||
Official Date: | 17 November 2020 | |||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 1 | |||||||||||||||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||||||||||||||
Article Number: | tgaa087 | |||||||||||||||||||||||||||||||||
DOI: | 10.1093/texcom/tgaa087 | |||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 6 January 2021 | |||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 8 January 2021 | |||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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