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Cariprazine in the management of negative symptoms of schizophrenia : state of the art and future perspectives
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Correll, Christoph U, Demyttenaere, Koen, Fagiolini, Andrea, Hajak, Göran, Pallanti, Stefano, Racagni, Giorgio and Singh, Swaran P. (2020) Cariprazine in the management of negative symptoms of schizophrenia : state of the art and future perspectives. Future Neurology, 15 (4). FNL52. doi:10.2217/fnl-2020-0012 ISSN 1479-6708.
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WRAP-cariprazine-management-negative-symptoms-schizophrenia-Singh-2020.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (2246Kb) | Preview |
Official URL: http://dx.doi.org/10.2217/fnl-2020-0012
Abstract
In schizophrenia, dopaminergic hyperactivity in the mesolimbic regions, or possibly even selectively so in the dorsal striatum, seems to cause the emergence of psychotic symptoms, whereas dopaminergic hypoactivity in cortical regions underlies the negative symptoms and cognitive deficits. Managing the negative symptoms is a major current challenge in the treatment of schizophrenia with a dearth of novel modalities to address this clinical issue. Cariprazine is a novel second-generation antipsychotic that specifically targets the D3 receptor mainly associated to negative symptoms. The review summarizes the main issues regarding negative symptom management and the role of cariprazine treatment.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Antipsychotic drugs, Schizophrenia, Dopamine | ||||||
| Journal or Publication Title: | Future Neurology | ||||||
| Publisher: | Future Medicine | ||||||
| ISSN: | 1479-6708 | ||||||
| Official Date: | 30 November 2020 | ||||||
| Dates: |
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| Volume: | 15 | ||||||
| Number: | 4 | ||||||
| Article Number: | FNL52 | ||||||
| DOI: | 10.2217/fnl-2020-0012 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 8 January 2021 | ||||||
| Date of first compliant Open Access: | 11 January 2021 | ||||||
| Is Part Of: | 1 |
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