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ILB ® resolves inflammatory scarring and promotes functional tissue repair
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Hill, Lisa J., Botfield, Hannah F., Begum, Ghazala, Qureshi, Omar, Vigneswara, Vasanthy, Masood, Imran, Barnes, Nicholas M., Bruce, Lars and Logan, Ann (2021) ILB ® resolves inflammatory scarring and promotes functional tissue repair. npj Regenerative Medicine, 6 (1). 3. doi:10.1038/s41536-020-00110-2 ISSN 2057-3995.
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Official URL: https://doi.org/10.1038/s41536-020-00110-2
Abstract
Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics. Compromised cellular and tissue repair processes following injury, infection, metabolic dysfunction, autoimmune conditions and vascular diseases leave tissues susceptible to unresolved inflammation, fibrogenesis, loss of function and scarring. There has been limited clinical success with therapies for inflammatory and fibrotic diseases such that there remains a large unmet therapeutic need to restore normal tissue homoeostasis without detrimental side effects. We investigated the effects of a newly formulated low molecular weight dextran sulfate (LMW-DS), termed ILB®, to resolve inflammation and activate matrix remodelling in rodent and human disease models. We demonstrated modulation of the expression of multiple pro-inflammatory cytokines and chemokines in vitro together with scar resolution and improved matrix remodelling in vivo. Of particular relevance, we demonstrated that ILB® acts, in part, by downregulating transforming growth factor (TGF)β signalling genes and by altering gene expression relating to extracellular matrix dynamics, leading to tissue remodelling, reduced fibrosis and functional tissue regeneration. These observations indicate the potential of ILB® to alleviate fibrotic diseases.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | npj Regenerative Medicine | ||||||
Publisher: | Nature Publishing Group UK | ||||||
ISSN: | 2057-3995 | ||||||
Official Date: | 7 January 2021 | ||||||
Dates: |
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Volume: | 6 | ||||||
Number: | 1 | ||||||
Article Number: | 3 | ||||||
DOI: | 10.1038/s41536-020-00110-2 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
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