How do benzylic amide catenane rings rotate?
UNSPECIFIED (1999) How do benzylic amide catenane rings rotate? JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 121 (11). pp. 2364-2379. ISSN 0002-7863Full text not available from this repository.
The structure and dynamics of three benzylic amide catenanes have been investigated using molecular mechanics and calculations employing unimolecular reaction rate theory. The study provides the first complete theoretical description of the lowest energy pathway for the circumrotation of macrocycles in a catenane system. The process is a concerted sequence of several large-amplitude motions which involve rearrangements to minimize steric and electrostatic interactions via the interplay of hydrogen bonding, formation of pi-stacks, phenyl-phenyl T-shaped interactions, and amide rotamer interconversions. In spite of this complexity, unifying features an found for the description of the passing of successive moieties through the macrocyclic cavities. Analysis of the structural characteristics of transition states located along the circumrotational pathway of the three catenanes (bearing phenyl-, pyridyl-, and thiophenyl-l,3-dicarbonyl groups) furnishes a simple mechanistic interpretation of the large variation of the dynamical behavior observed in temperature-dependent NMR experiments. Calculations of the rate constants provide the ultimate insight into the complicated dynamics of these molecules, showing that the rate-determining steps do not necessarily correspond to the passage of the bulkiest groups and that, like a cog or rotor system, rotation of one macrocyclic ring induces, or makes easier, rotation of the other.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||JOURNAL OF THE AMERICAN CHEMICAL SOCIETY|
|Publisher:||AMER CHEMICAL SOC|
|Date:||24 March 1999|
|Number of Pages:||16|
|Page Range:||pp. 2364-2379|
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