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Myosin driven actin filament sliding is responsible for endoplasmic reticulum and golgi movement
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McKenna, Joseph F., Webb, Stephen E. D., Kriechbaumer, Verena and Hawes, Chris (2018) Myosin driven actin filament sliding is responsible for endoplasmic reticulum and golgi movement. Working Paper. Cold Spring Harbor: bioRXiv.
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Official URL: http://dx.doi.org/10.1101/347187
Abstract
The plant secretory pathway is responsible for the production of the majority of proteins and carbohydrates consumed on the planet. The early secretory pathway is composed of Golgi bodies and the endoplasmic reticulum (ER) and is highly mobile in plants with rapid remodelling of the ER network. The dynamics of the ER and Golgi bodies is driven by the actin cytoskeleton and myosin motor proteins play a key role in this. However, exactly how myosin motor proteins drive remodelling in plants is currently a contentious issue. Here, using a combination of live cell microscopy and over-expression of non-functional myosins we demonstrate that myosin motor proteins drive actin filament sliding and subsequently the dynamics of the secretory pathway.
Item Type: | Working or Discussion Paper (Working Paper) | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Publisher: | bioRXiv | ||||
Place of Publication: | Cold Spring Harbor | ||||
Book Title: | Myosin driven Actin Filament Sliding is Responsible for Endoplasmic Reticulum and Golgi Movement | ||||
Official Date: | December 2018 | ||||
Dates: |
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DOI: | 10.1101/347187 | ||||
Institution: | University of Warwick | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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