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Chemical probes reveal the timing of early chlorination in vancomycin biosynthesis

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Leng, Daniel J., Greule, Anja, Cryle, Max J. and Tosin, Manuela (2021) Chemical probes reveal the timing of early chlorination in vancomycin biosynthesis. Chemical Communications, 57 (18). pp. 2293-2296. doi:10.1039/D0CC07421G ISSN 1359-7345.

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Official URL: http://dx.doi.org/10.1039/D0CC07421G

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Abstract

Glycopeptides such as vancomycin are antibiotics of last resort whose biosynthetic pathways still hold undefined details. Chemical probes were used to capture biosynthetic intermediates generated in the nonribosomal peptide formation of vancomycin in vivo. The putative intercepted intermediates were characterised via HR-LC-MS2. These species provided insights into the timing of the first chlorination of the peptide backbone by the halogenase VhaA: this holds significant interest for enzyme engineering towards the making of novel glycopeptides.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Vancomycin, Vancomycin resistance , Peptides -- Synthesis, Glycopeptides
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 2021
Dates:
DateEvent
2021Published
26 January 2021Available
26 January 2021Accepted
Volume: 57
Number: 18
Page Range: pp. 2293-2296
DOI: 10.1039/D0CC07421G
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 17 February 2021
Date of first compliant Open Access: 18 February 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/J007250/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
MIBTP studentship[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
Monash Warwick Alliance Seed Fund AwardUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741

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