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Greater preference for eveningness is associated with negative symptoms in an ultra-high risk for psychosis sample
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Shetty, Jashmina J., Nicholas, Christian, Nelson, Barnaby, McGorry, Patrick D., Lavoie, Suzie, Markulev, Connie, Schäfer, Miriam R., Thompson, Andrew D., Yuen, Hok Pan, Yung, Alison R., Nieman, Dorien H., de Haan, Lieuwe, Amminger, G. Paul and Hartmann, Jessica A. (2021) Greater preference for eveningness is associated with negative symptoms in an ultra-high risk for psychosis sample. Early Intervention in Psychiatry, 15 (6). pp. 1793-1798. doi:10.1111/eip.13112 ISSN 1751-7885.
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Official URL: http://dx.doi.org/10.1111/eip.13112
Abstract
Aim:
Investigating biological processes in at-risk individuals may help elucidate the aetiological mechanisms underlying psychosis development, refine prediction models and improve intervention strategies. This study examined the associations between sleep disturbances, chronotype, depressive and psychotic symptoms in individuals at ultra-high risk for psychosis.
Methods:
A sample of 81 ultra-high risk patients completed clinical interviews and self-report assessments of chronotype and sleep during the Neurapro clinical trial. Mixed regression was used to investigate the cross-sectional associations between symptoms and sleep disturbances/chronotype.
Results:
Sleep disturbances were significantly associated with increased depressive and attenuated positive psychotic symptoms. Greater preference for eveningness was significantly associated with increased negative symptoms, but not with depressive or attenuated positive psychotic symptoms.
Conclusion:
Sleep disturbances and chronotype may impact the emerging psychopathology experienced by ultra-high risk individuals. Further, the preliminary relationship observed between greater preference for eveningness and negative symptoms offers a unique opportunity to treat negative symptoms through chronobiological approaches.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Early Intervention in Psychiatry | ||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
ISSN: | 1751-7885 | ||||||||
Official Date: | December 2021 | ||||||||
Dates: |
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Volume: | 15 | ||||||||
Number: | 6 | ||||||||
Page Range: | pp. 1793-1798 | ||||||||
DOI: | 10.1111/eip.13112 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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