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A case of failed oocyte maturation in vivo and in vitro
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UNSPECIFIED (1999) A case of failed oocyte maturation in vivo and in vitro. FERTILITY AND STERILITY, 71 (3). pp. 567-570. ISSN 0015-0282.
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Abstract
Objective: To study a couple for whom all oocytes failed to mature during three attempts at IVF/ICSI treatment. Our aims were (a) to promote oocyte maturation in vitro and (b) to identify the stage of maturation arrest.
Design: Case report.
Setting: Infertility treatment center with academic research links.
Patient(s): Couple with unexplained infertility.
Intervention(s): Exogenous gonadotropin stimulation culminating in the retrieval of right oocyte-cumulus complexes that were exposed to gonadotropins for 24 hours in vitro.
Main Outcome Measure(s): Observation of oocyte cumulus complexes, measurements of oocyte diameter, oocyte chromatin staining with Hoechst 33258,
Result(s): The cumulus complexes varied in appearance and expanded in vitro, but yielded immature oocytes. Germinal vesicle breakdown occurred in all oocytes;and chromatin was consistent with arrest at entry into M-phase. The oocytes were of a size normally competent to mature.
Conclusion(s): Infertility in this couple was attributed to the failure of oocytes to enter M-phase. This was not overcome by exposure to gonadotropins in vitro nor associated with incompetence due to small oocyte size. (Fertil Steril(R) 1999;71.567-70. (C) 1999 by American Society for Reproductive Medicine.)
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
Journal or Publication Title: | FERTILITY AND STERILITY | ||||
Publisher: | ELSEVIER SCIENCE INC | ||||
ISSN: | 0015-0282 | ||||
Official Date: | March 1999 | ||||
Dates: |
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Volume: | 71 | ||||
Number: | 3 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 567-570 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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