UNSPECIFIED (1999) A case of failed oocyte maturation in vivo and in vitro. FERTILITY AND STERILITY, 71 (3). pp. 567-570. ISSN 0015-0282

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Abstract

Objective: To study a couple for whom all oocytes failed to mature during three attempts at IVF/ICSI treatment. Our aims were (a) to promote oocyte maturation in vitro and (b) to identify the stage of maturation arrest. Design: Case report. Setting: Infertility treatment center with academic research links. Patient(s): Couple with unexplained infertility. Intervention(s): Exogenous gonadotropin stimulation culminating in the retrieval of right oocyte-cumulus complexes that were exposed to gonadotropins for 24 hours in vitro. Main Outcome Measure(s): Observation of oocyte cumulus complexes, measurements of oocyte diameter, oocyte chromatin staining with Hoechst 33258, Result(s): The cumulus complexes varied in appearance and expanded in vitro, but yielded immature oocytes. Germinal vesicle breakdown occurred in all oocytes;and chromatin was consistent with arrest at entry into M-phase. The oocytes were of a size normally competent to mature. Conclusion(s): Infertility in this couple was attributed to the failure of oocytes to enter M-phase. This was not overcome by exposure to gonadotropins in vitro nor associated with incompetence due to small oocyte size. (Fertil Steril(R) 1999;71.567-70. (C) 1999 by American Society for Reproductive Medicine.)

Item Type:	Journal Article
Subjects:	R Medicine > RG Gynecology and obstetrics
Journal or Publication Title:	FERTILITY AND STERILITY
Publisher:	ELSEVIER SCIENCE INC
ISSN:	0015-0282
Date:	March 1999
Volume:	71
Number:	3
Number of Pages:	4
Page Range:	pp. 567-570
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/14871

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