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Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England : a time trend analysis

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Vohra, Neha, Hadi, Muhammad Abdul, Khanal, Saval, Kurmi, Om P. and Paudyal, Vibhu (2021) Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England : a time trend analysis. British Journal of Clinical Pharmacology, 87 (10). pp. 3747-3755. doi:10.1111/bcp.14782

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Abstract

Aim:
This study aimed to examine trends in prescribing of anti‐dementia drugs in primary care in England between 2009‐2019 and investigate the impact of deprivation, regional demography and disease prevalence on prescribing practices.

Methods:
Analysis of publicly available government data from various sources pertaining to primary care prescribing and demographics was conducted. All primary care prescription data pertaining to anti‐dementia drugs in England between 2009‐2019 were extracted and adjusted for inflation and populations changes. Data across English Clinical Commissioning regions were compared to explore the association between prescribing trend, deprivation, regional demography and dementia prevalence.

Results:
The number of prescription items for anti‐dementia drugs in England increased by approximately three‐folds (195.4%) from 24 items/1,000 populations in 2009 to 70.9 items/1,000 populations in 2019. In 2019, the least deprived areas had approximately twice the rate of prescribing of anti‐dementia drugs compared to the most deprived areas [median (IQR) values of 46.7 (36.6‐64.8) vs 91.23 (76.2‐95.1) items/1,000 populations respectively]. In the multivariable analysis, the number of prescription items showed an inverse relationship with deprivation [Coeff ‐0.046 95%CI:‐0.47 to ‐0.045] after adjustment of populations 65+ years and prevalence of dementia.

Conclusions:
The three‐fold rise in the number of prescription items for anti‐dementia drugs in the study period reflects the policy emphasis on early diagnosis and treatment of dementia. Higher rates of prescribing in the least deprived areas may be reflective of better and early diagnoses and access to treatments. Such inequality in access to the treatments needs to be investigated further.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Social Sciences > Warwick Business School > Behavioural Science
Faculty of Social Sciences > Warwick Business School
Library of Congress Subject Headings (LCSH): Dementia, Dementia -- Patients -- Care, Dementia -- Treatment, Antipsychotic drugs , Drugs -- Prescribing -- England
Journal or Publication Title: British Journal of Clinical Pharmacology
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0306-5251
Official Date: October 2021
Dates:
DateEvent
October 2021Published
18 February 2021Available
12 February 2021Accepted
Volume: 87
Number: 10
Page Range: pp. 3747-3755
DOI: 10.1111/bcp.14782
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: This is the peer reviewed version of the following article: Vohra, N, Hadi, MA, Khanal, S, Kurmi, OP, Paudyal, V. Impact of deprivation, dementia prevalence and regional demography on prescribing of anti‐dementia drugs in England: a time trend analysis. Br J Clin Pharmacol. 2021. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/bcp.14782. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDUniversity Of Birminghamhttp://dx.doi.org/10.13039/501100000855
Open Access Version:
  • https://bpspubs.onlinelibrary.wiley.com/...

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