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Relationship between maternal bone biomarkers and fetal adiposity through normal pregnancy
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Mastorakos, George, Maliopoulos, D., Kassioni, S., Bargiota, A., Barber, Thomas M., Skevaki, C., Papassotiriou, I., Farmakides, G., Vlachos, N., Kumar, Sudhesh and Valsamakis, Georgios (2021) Relationship between maternal bone biomarkers and fetal adiposity through normal pregnancy. Journal of Clinical Endocrinology and Metabolism . dgab152. doi:10.1210/clinem/dgab152 (In Press)
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WRAP-Relationship-maternal-bone-biomarkers-fetal-adiposity-normal-pregnancy-2021.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 12 March 2022. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (1419Kb) |
Official URL: https://doi.org/10.1210/clinem/dgab152
Abstract
Purpose
To examine the association of maternal bone markers (sclerostin, sRANKL, osteocalcin, 25OHD3) with fetal intra-abdominal and subcutaneous adipose tissue deposition and birthweight during normal pregnancy.
Methods
One hundred pregnant women (aged 30.4±5.6 years, mean±SD) with pre-pregnancy BMI=24.1±4.6 kg/m² were seen prospectively during each trimester. At each visit they were submitted to anthropometric measurements, a fasting blood sampling, a 75gr oral glucose tolerance test (OGTT) and a fetal ultrasonogram. At birth, neonates had birth weight measurement.
Results
In the 2 nd trimester maternal sclerostin concentrations correlated positively with fetal abdominal circumference and birth weight; maternal sRANKL concentrations correlated positively with fetal abdominal subcutaneous fat thickness, sagittal abdominal diameter and abdominal circumference. Fetuses born to mothers with greater (>254 ng/mL) compared to fetuses born to mothers with lower (≤254 ng/mL) sRANKL concentrations had greater abdominal circumference, sagittal diameter and abdominal subcutaneous fat thickness. Maternal serum sclerostin concentrations were the best positive predictors of birth weight. In the 3 rd trimester maternal sclerostin concentrations correlated positively with fetal sagittal abdominal diameter; maternal sRANKL concentrations positively correlated with fetal abdominal circumference and fetal abdominal sagittal diameter.
Conclusions
Maternal bone markers sclerostin and sRANKL may relate with fetal intra-abdominal adipose tissue deposition through direct or indirect unknown as yet mechanisms contributing thus, to birthweight.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Biochemical markers , Bones -- Diseases -- Diagnosis, Birth weight , Pregnancy | ||||||
| Journal or Publication Title: | Journal of Clinical Endocrinology and Metabolism | ||||||
| Publisher: | The Endocrine Society | ||||||
| ISSN: | 0021-972X | ||||||
| Official Date: | 12 March 2021 | ||||||
| Dates: |
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| Article Number: | dgab152 | ||||||
| DOI: | 10.1210/clinem/dgab152 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | In Press | ||||||
| Publisher Statement: | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Clinical Endocrinology and Metabolism following peer review. The version of record George Mastorakos, Dimosthenis Maliopoulos, Spyridoula Kasioni, Alexandra Bargiota, Thomas Μ Barber, Chrysanthi Skevaki, Ioannis Papassotiriou, Nikos Vrachnis, George Farmakides, Nikos F Vlahos, Sudhesh Kumar, Georgios Valsamakis, Relationship between maternal bone biomarkers and fetal adiposity through normal pregnancy, The Journal of Clinical Endocrinology & Metabolism, 2021;, dgab152, is available online at: https://doi.org/10.1210/clinem/dgab152 | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
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