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Decreased amygdala volume in adults after premature birth

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Schmitz-Koep, Benita, Zimmermann, Juliana, Menegaux, Aurore, Nuttall, Rachel, Bäuml, Josef G., Schneider, Sebastian C., Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Wolke, Dieter, Bartmann, Peter, Hedderich, Dennis M. and Sorg, Christian (2021) Decreased amygdala volume in adults after premature birth. Scientific Reports, 11 (1). 5403. doi:10.1038/s41598-021-84906-2

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Official URL: http://dx.doi.org/10.1038/s41598-021-84906-2

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Abstract

Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this problem, we stated the following questions: first, are whole amygdala volumes reduced in premature-born adults? And second, as adult anxiety traits are often increased after prematurity and linked with amygdala structure, are alterations in amygdala associated with adults’ anxiety traits after premature birth? We addressed these questions by automated amygdala segmentation of MRI volumes in 101 very premature-born adults (< 32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls at 26 years of age of a prospectively and longitudinally collected cohort. We found significantly lower whole amygdala volumes in premature-born adults. While premature-born adults had significantly higher T score for avoidant personality reflecting increased social anxiety trait, this trait was not correlated with amygdala volume alterations. Results demonstrate reduced amygdala volumes in premature born adults. Data suggest lasting effects of prematurity on amygdala structure.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science > Psychology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Premature infants, Premature infants -- Development , Premature infants -- Physiology, Amygdaloid body, Anxiety -- Diagnosis , Anxiety disorders -- Diagnosis
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
Official Date: 8 March 2021
Dates:
DateEvent
8 March 2021Published
22 February 2021Accepted
Volume: 11
Number: 1
Article Number: 5403
DOI: 10.1038/s41598-021-84906-2
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
SO 1336/1-1 [DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BMBF 01ER0801 Bundesministerium für Bildung, Wissenschaft, Forschung und Technologiehttp://dx.doi.org/10.13039/501100010571
BMBF 01ER0803 Bundesministerium für Bildung, Wissenschaft, Forschung und Technologiehttp://dx.doi.org/10.13039/501100010571
KKF 8765162 Technische Universität Münchenhttp://viaf.org/viaf/145299462
KKF8700000474 Technische Universität Münchenhttp://viaf.org/viaf/145299462

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