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Modelling sand fly Lutzomyia longipalpis attraction to host odour : a synthetic sex-aggregation pheromone dominates the response

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Retkute, Renata, Dilger, Erin, Hamilton, James G. C., Keeling, Matthew James and Courtenay, Orin (2021) Modelling sand fly Lutzomyia longipalpis attraction to host odour : a synthetic sex-aggregation pheromone dominates the response. Microorganisms, 9 (3). 602. doi:10.3390/microorganisms9030602 ISSN 2076-2607.

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Official URL: https://doi.org/10.3390/microorganisms9030602

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Abstract

Zoontic visceral leishmaniasis (ZVL) due to Leishmania infantum is a potentially fatal protozoan parasitic disease of humans and dogs. In the Americas, dogs are the reservoir and the sand fly, Lutzomyia longipalpis, the principal vector. A synthetic version of the male sand fly produced sex-aggregation pheromone attracts both female and male conspecifics to co-located insecticide, reducing both reservoir infection and vector abundance. However the effect of the synthetic pheromone on the vector’s “choice“ of host (human, animal reservoir, or dead-end host) for blood feeding in the presence of the pheromone is less well understood. In this study, we developed a modelling framework to allow us to predict the relative attractiveness of the synthetic pheromone and potential alterations in host choice. Our analysis indicates that the synthetic pheromone can attract 53% (95% CIs: 39%–86%) of host-seeking female Lu. longipalpis and thus it out-competes competing host odours. Importantly, the results suggest that the synthetic pheromone can lure vectors away from humans and dogs, such that when co-located with insecticide, it provides protection against transmission leading to human and canine ZVL.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Leishmania , Dogs -- Diseases -- Prevention, Lutzomyia, Sand flies, Pheromones -- Receptors -- Simulation methods
Journal or Publication Title: Microorganisms
Publisher: MDPI
ISSN: 2076-2607
Official Date: 15 March 2021
Dates:
DateEvent
15 March 2021Published
12 March 2021Accepted
Volume: 9
Number: 3
Article Number: 602
DOI: 10.3390/microorganisms9030602
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 15 March 2021
Date of first compliant Open Access: 22 March 2021
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