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Modelling sand fly Lutzomyia longipalpis attraction to host odour : a synthetic sex-aggregation pheromone dominates the response
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Retkute, Renata, Dilger, Erin, Hamilton, James G. C., Keeling, Matthew James and Courtenay, Orin (2021) Modelling sand fly Lutzomyia longipalpis attraction to host odour : a synthetic sex-aggregation pheromone dominates the response. Microorganisms, 9 (3). 602. doi:10.3390/microorganisms9030602
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Official URL: https://doi.org/10.3390/microorganisms9030602
Abstract
Zoontic visceral leishmaniasis (ZVL) due to Leishmania infantum is a potentially fatal protozoan parasitic disease of humans and dogs. In the Americas, dogs are the reservoir and the sand fly, Lutzomyia longipalpis, the principal vector. A synthetic version of the male sand fly produced sex-aggregation pheromone attracts both female and male conspecifics to co-located insecticide, reducing both reservoir infection and vector abundance. However the effect of the synthetic pheromone on the vector’s “choice“ of host (human, animal reservoir, or dead-end host) for blood feeding in the presence of the pheromone is less well understood. In this study, we developed a modelling framework to allow us to predict the relative attractiveness of the synthetic pheromone and potential alterations in host choice. Our analysis indicates that the synthetic pheromone can attract 53% (95% CIs: 39%–86%) of host-seeking female Lu. longipalpis and thus it out-competes competing host odours. Importantly, the results suggest that the synthetic pheromone can lure vectors away from humans and dogs, such that when co-located with insecticide, it provides protection against transmission leading to human and canine ZVL.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QL Zoology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Leishmania , Dogs -- Diseases -- Prevention, Lutzomyia, Sand flies, Pheromones -- Receptors -- Simulation methods | ||||||
| Journal or Publication Title: | Microorganisms | ||||||
| Publisher: | MDPI | ||||||
| ISSN: | 2076-2607 | ||||||
| Official Date: | 15 March 2021 | ||||||
| Dates: |
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| Volume: | 9 | ||||||
| Number: | 3 | ||||||
| Article Number: | 602 | ||||||
| DOI: | 10.3390/microorganisms9030602 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
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