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Comparing an imaging-guided pathway with the standard pathway for staging muscle-invasive bladder cancer : preliminary data from the BladderPath study
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Bryan, Richard T., Liu, Wenyu, Pirrie, Sarah J., Amir, Rashid, Gallagher, Jean, Hughes, Ana I., Jefferson, Kieran P., Knight, Allen, Nanton, Veronica, Mintz, Harriet P., Pope, Ann M, Catto, James W. F., Patel, Prashant and James, Nicholas D. (2021) Comparing an imaging-guided pathway with the standard pathway for staging muscle-invasive bladder cancer : preliminary data from the BladderPath study. European Urology, 80 (1). pp. 12-15. doi:10.1016/j.eururo.2021.02.021 ISSN 0302-2838.
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Official URL: http://dx.doi.org/10.1016/j.eururo.2021.02.021
Abstract
Transurethral resection of bladder tumour (TURBT) is central to the diagnosis of muscle-invasive bladder cancer (MIBC). With the oncological safety of TURBT unknown, staging inaccuracies commonplace, and correct treatment of MIBC potentially delayed, multiparametric magnetic resonance imaging (mpMRI) may offer rapid, accurate, and noninvasive diagnosis of MIBC. BladderPath is a randomised trial comparing risk-stratified (5-point Likert scale) image-directed care with TURBT for patients with newly diagnosed BC. To date, we have screened 279 patients and randomised 113. Here we report on the first 100 participants to complete staging: 48 in pathway 1 (TURBT) and 52 in pathway 2 (mpMRI for possible MIBC, Likert 3-5). Fifty of 52 participants designated Likert 1-2 (probable NMIBC) from both pathways were confirmed as having NMIBC (96%). Ten of 11 cases diagnosed as NMIBC by mpMRI have been pathologically confirmed as NMIBC, and 10/15 cases diagnosed as MIBC by mpMRI have been treated as MIBC (5 participants underwent TURBT). The specificity of mpMRI for identification of MIBC remains a limitation. These initial experiences indicate that it is feasible to direct possible MIBC patients to mpMRI for staging instead of TURBT. Furthermore, a 5-point Likert scale accurately identifies patients with low risk of MIBC (Likert 1-2), and flexible cystoscopy biopsies appear sufficient for diagnosing BC. PATIENT SUMMARY: We are conducting a clinical trial to assess whether some bladder tumour surgery can be replaced by magnetic resonance imaging scans to determine the stage of the cancer in patients whose tumours appear to be invasive. Our early data suggest that this approach is feasible. The data also show that using a visual score ('Likert scale') can help to identify bladder tumours that are very unlikely to be invasive, and that taking a biopsy in the outpatient clinic when first inspecting the bladder via a camera (diagnostic flexible cystoscopy) is useful for confirming bladder cancer. [Abstract copyright: Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.]
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | European Urology | ||||||||
Publisher: | Elsevier BV | ||||||||
ISSN: | 0302-2838 | ||||||||
Official Date: | July 2021 | ||||||||
Dates: |
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Volume: | 80 | ||||||||
Number: | 1 | ||||||||
Page Range: | pp. 12-15 | ||||||||
DOI: | 10.1016/j.eururo.2021.02.021 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
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