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Synthesis and self-assembly of corona-functionalised polymeric arsenical nanoparticles

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Tobin, Hayden, Liarou, Evelina, Song, Ji-Inn, Magiakos, Alexandros and Wilson, Paul (2020) Synthesis and self-assembly of corona-functionalised polymeric arsenical nanoparticles. European Polymer Journal, 144 . 110235. doi:10.1016/j.eurpolymj.2020.110235

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Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2020.110235

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Abstract

Polymeric arsenicals are emerging as an interesting platform for functional and (re)active materials in the field of polymer and (bio)materials science. Through exploiting the diverse and distinct reactivity of organic arsenicals in As(V), As(III) and As(I) oxidation states efficient methods for bioconjugation as well as hydrogel and nanoparticles formation have been reported. Here we expand on this body of work by reporting the synthesis of new amphiphilic block copolymeric arsenicals with a target composition of P((DMAm100-X-co-AsAmX)-b-DAAm100) (P1, X = 0; P2, X = 5; P3, X = 20) which form nanoparticles (NP1–NP3; Dh = 49–71 nm) upon self-assembly in water. The mole fraction of the AsAm monomer appears to have an effect on the particle morphology and stability, with stability decreasing as a function of the AsAm mole fraction in the corona. The reactivity of the AsAm (As(V)) group has been exploited to modify the corona functionality via direct reduction (NPRed) and sequential reduction and thiol substitution (NPGSH). The resulting As(III)-functionalised nanoparticles (NPRed) exhibited concentration-dependent toxicity against human prostate adenocarcinoma epithelia cell (PC-3) alluding to future development of these particles for mono- or combination therapy within appropriate nanoparticle formulations.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Arsenic compounds, Crosslinking (Polymerization), Organometallic polymers , Nanoparticles -- Synthesis
Journal or Publication Title: European Polymer Journal
Publisher: Pergamon
ISSN: 0014-3057
Official Date: 5 February 2020
Dates:
DateEvent
5 February 2020Published
22 December 2020Available
18 December 2020Accepted
Volume: 144
Article Number: 110235
DOI: 10.1016/j.eurpolymj.2020.110235
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
URF\R1\180274Royal Societyhttp://dx.doi.org/10.13039/501100000288
URF\R1\180274Tata Steelhttp://dx.doi.org/10.13039/501100007220
UNSPECIFIEDErasmus+http://dx.doi.org/10.13039/501100010790

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