Henry, Stuart Adam (2019) Brønsted acid-based strategies for N-heterocyclic synthesis. PhD thesis, University of Warwick.

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Abstract

The focal point of this work has been the development of new and expedient Brønsted acid–catalysed synthetic methods with alcohol pro–electrophiles to rapidly achieve molecular complexity.

Chapter 1 provides insight into notable developments within the field of Brønsted acid–mediated transformations of alcohols as pro–electrophiles.

Chapter 2 describes our efforts towards the realisation of a chiral Brønsted acid– catalysed enantioselective 1,3–allylic alcohol isomerisation of 3–indolinols.

Chapter 3 describes the synthesis of 1,2–dihydroquinolines via a Brønsted acid–catalysed intramolecular allylic amination.

Chapter 4 is an account of the Brønsted acid–catalysed cyclisation of b–amino–1,4– enols to oxazol–2(3H)–ones and 5–alkenyloxazolidin–2–ones.

Chapter 5 provides a summary of the works presented herein.

Chapter 6 details the experimental data and methods used in the work presented in this thesis.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH):	Heterocyclic compounds -- Synthesis, Catalysis, Electrophiles
Official Date:	August 2019
Dates:	Date Event August 2019 UNSPECIFIED
Institution:	University of Warwick
Theses Department:	Department of Chemistry
Thesis Type:	PhD
Publication Status:	Unpublished
Supervisor(s)/Advisor:	Chan, Philip Wai Hong
Sponsors:	Engineering and Physical Sciences Research Council ; University of Warwick
Format of File:	pdf
Extent:	vii, 198 leaves : illustrations (some colour)
Language:	eng

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