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Investigating the molecular guts of endoderm formation using zebrafish
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Figiel, Daniela M., Elsayed, Randa and Nelson, Andrew (2021) Investigating the molecular guts of endoderm formation using zebrafish. Briefings in Functional Genomics, 20 (6). pp. 394-406. doi:10.1093/bfgp/elab013 ISSN 2041-2657.
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Official URL: https://doi.org/10.1093/bfgp/elab013
Abstract
The vertebrate endoderm makes major contributions to the respiratory and gastrointestinal tracts and all associated organs. Zebrafish and humans share a high degree of genetic homology and strikingly similar endodermal organ systems. Combined with a multitude of experimental advantages, zebrafish are an attractive model organism to study endoderm development and disease. Recent functional genomics studies have shed considerable light on the gene regulatory programs governing early zebrafish endoderm development, while advances in biological and technological approaches stand to further revolutionize our ability to investigate endoderm formation, function and disease. Here, we discuss the present understanding of endoderm specification in zebrafish compared to other vertebrates, how current and emerging methods will allow refined and enhanced analysis of endoderm formation, and how integration with human data will allow modeling of the link between non-coding sequence variants and human disease.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Briefings in Functional Genomics | ||||||||
Publisher: | Oxford University Press (OUP) | ||||||||
ISSN: | 2041-2657 | ||||||||
Official Date: | November 2021 | ||||||||
Dates: |
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Volume: | 20 | ||||||||
Number: | 6 | ||||||||
Page Range: | pp. 394-406 | ||||||||
DOI: | 10.1093/bfgp/elab013 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | ** Article version: VoR ** From Crossref journal articles via Jisc Publications Router ** History: epub 23-03-2021; issued 23-03-2021. ** Licence for VoR version of this article starting on 23-03-2021: https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 September 2022 | ||||||||
Date of first compliant Open Access: | 27 September 2022 | ||||||||
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