Cowman, Megan, Holleran, Laurena, Lonergan, Edgar, O'Connor, Karen, Birchwood, Max and Donohoe, Gary (2021) Cognitive predictors of social and occupational functioning in early psychosis : a systematic review and meta-analysis of cross-sectional and longitudinal data. Schizophrenia Bulletin, 47 (5). pp. 1243-1253. doi:10.1093/schbul/sbab033 ISSN 0586-7614.

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Abstract

Many individuals with early psychosis experience impairments in social and occupational function. Identification of modifiable predictors of function such as cognitive performance has the potential to inform effective treatments. Our aim was to estimate the strength of the relationship between psychosocial function in early psychosis and different domains of cognitive and social cognitive performance. We conducted a systematic review and meta-analysis of peer-reviewed, cross-sectional, and longitudinal studies examining cognitive predictors of psychosocial function. Literature searches were conducted in PsycINFO, PubMed, and reference lists of relevant articles to identify studies for inclusion. Of the 2565 identified, 46 studies comprising 3767 participants met inclusion criteria. Separate meta-analyses were conducted for 9 cognitive domains. Pearson correlation values between cognitive variables and function were extracted. All cognitive domains were related to psychosocial function both cross-sectionally and longitudinally. Importantly, these associations remained significant even after the effects of symptom severity, duration of untreated psychosis, and length of illness were accounted for. Overall, general cognitive ability and social cognition were most strongly associated with both concurrent and long-term function. Associations demonstrated medium effect sizes. These findings suggest that treatments targeting cognitive deficits, in particular those focusing on social cognition, are likely to be important for improving functional outcomes in early psychosis. [Abstract copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: journals.permissions@oup.com.]

Item Type:	Journal Article
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor:	Library Publications Router
Library of Congress Subject Headings (LCSH):	Schizophrenia, Schizophrenia -- Diagnosis -- Cross-cultural studies , Cognition , Social perception
Journal or Publication Title:	Schizophrenia Bulletin
Publisher:	Oxford University Press
ISSN:	0586-7614
Official Date:	September 2021
Dates:	Date Event September 2021 Published 24 March 2021 Available 10 February 2021 Accepted
Volume:	47
Number:	5
Page Range:	pp. 1243-1253
DOI:	10.1093/schbul/sbab033
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Copyright Holders:	© The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center
Date of first compliant deposit:	13 July 2021
Date of first compliant Open Access:	13 July 2021
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID RL-2020-007 Ireland‏. Health Research Board http://viaf.org/viaf/143343795

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