Superoxide generation from constitutive nitric oxide synthase in astrocytes in vitro regulates extracellular nitric oxide availability
UNSPECIFIED (1999) Superoxide generation from constitutive nitric oxide synthase in astrocytes in vitro regulates extracellular nitric oxide availability. FREE RADICAL BIOLOGY AND MEDICINE, 26 (1-2). pp. 99-106. ISSN 0891-5849Full text not available from this repository.
Oxygen-derived free radicals play an important role in the physiology and pathophysiology of brain cell function. Because of their labile nature, however, it has been difficult to investigate their actions directly. This problem has been addressed, in primary rat brain cell cultures, in this study by utilization of two novel electrochemical sensors. It has been demonstrated that extracellular superoxide originates from the astrocytic subpopulation in a calcium/calmodulin dependent manner and responds to constitutive nitric oxide synthase inhibition. The results indicate a novel function for the astrocytic constitutive nitric oxide synthase in regulating extracellular superoxide release and, therefore, controlling neuronal nitric oxide availability. (C) 1998 Elsevier Science Inc.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
R Medicine > RC Internal medicine
|Journal or Publication Title:||FREE RADICAL BIOLOGY AND MEDICINE|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Number of Pages:||8|
|Page Range:||pp. 99-106|
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