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Association between self-reported signs and symptoms and SARS-CoV-2 antibody detection in UK key workers

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Mulchandani, Ranya, Taylor-Philips, Sian, Jones, Hayley E., Ades, A. E., Borrow, Ray, Linley, Ezra, Kirwan, Peter D., Stewart, Richard, Moore, Philippa, Boyes, John, Hormis, Anil, Todd, Neil, Colda, Antoanela, Reckless, Ian, Brooks, Tim, Charlett, Andre, Hickman, Matthew, Oliver, Isabel and Wyllie, David (2021) Association between self-reported signs and symptoms and SARS-CoV-2 antibody detection in UK key workers. The Journal of infection, 82 (5). pp. 151-161. doi:10.1016/j.jinf.2021.03.019 ISSN 1532-2742.

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Official URL: https://doi.org/10.1016/j.jinf.2021.03.019

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Abstract

Background
Screening for SARS-CoV-2 antibodies is under way in some key worker groups; how this adds to self-reported COVID-19 illness is unclear. In this study, we investigate the association between self-reported belief of COVID-19 illness and seropositivity.

Methods
Cross-sectional study of three key worker streams comprising (A) Police and Fire & Rescue (2 sites) (B) healthcare workers (1 site) and (C) healthcare workers with previously positive PCR result (5 sites). We collected self-reported signs and symptoms of COVID-19 and compared this with serology results from two SARS-CoV-2 immunoassays (Roche Elecsys® and EUROIMMUN).

Results
Between 01 and 26 June, we recruited 2847 individuals (Stream A: 1,247, Stream B: 1,546 and Stream C: 154). Amongst those without previous positive PCR tests, 687/2,579 (26%) reported belief they had COVID-19, having experienced compatible symptoms; however, only 208 (30.3%) of these were seropositive on both immunoassays. Both immunoassays had high sensitivities relative to previous PCR positivity (>93%); there was also limited decline in antibody titres up to 110 days post symptom onset. Symptomatic but seronegative individuals had differing symptom profiles and shorter illnesses than seropositive individuals.

Conclusion
Non-COVID-19 respiratory illness may have been mistaken for COVID-19 during the outbreak; laboratory testing is more specific than self-reported key worker beliefs in ascertaining past COVID-19 disease.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): COVID-19 (Disease) -- Diagnosis -- Great Britain, Immunoglobulins -- Diagnostic use, Serology
Journal or Publication Title: The Journal of infection
Publisher: Elsevier
ISSN: 1532-2742
Official Date: 1 May 2021
Dates:
DateEvent
1 May 2021Published
26 March 2021Available
19 March 2021Accepted
Volume: 82
Number: 5
Page Range: pp. 151-161
DOI: 10.1016/j.jinf.2021.03.019
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 14 April 2022
Date of first compliant Open Access: 14 April 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
CDF-2016–09–018[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
Is Part Of: 1

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