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Association between self-reported signs and symptoms and SARS-CoV-2 antibody detection in UK key workers
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Mulchandani, Ranya, Taylor-Philips, Sian, Jones, Hayley E., Ades, A. E., Borrow, Ray, Linley, Ezra, Kirwan, Peter D., Stewart, Richard, Moore, Philippa, Boyes, John, Hormis, Anil, Todd, Neil, Colda, Antoanela, Reckless, Ian, Brooks, Tim, Charlett, Andre, Hickman, Matthew, Oliver, Isabel and Wyllie, David (2021) Association between self-reported signs and symptoms and SARS-CoV-2 antibody detection in UK key workers. The Journal of infection, 82 (5). pp. 151-161. doi:10.1016/j.jinf.2021.03.019
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Official URL: https://doi.org/10.1016/j.jinf.2021.03.019
Abstract
Background
Screening for SARS-CoV-2 antibodies is under way in some key worker groups; how this adds to self-reported COVID-19 illness is unclear. In this study, we investigate the association between self-reported belief of COVID-19 illness and seropositivity.
Methods
Cross-sectional study of three key worker streams comprising (A) Police and Fire & Rescue (2 sites) (B) healthcare workers (1 site) and (C) healthcare workers with previously positive PCR result (5 sites). We collected self-reported signs and symptoms of COVID-19 and compared this with serology results from two SARS-CoV-2 immunoassays (Roche Elecsys® and EUROIMMUN).
Results
Between 01 and 26 June, we recruited 2847 individuals (Stream A: 1,247, Stream B: 1,546 and Stream C: 154). Amongst those without previous positive PCR tests, 687/2,579 (26%) reported belief they had COVID-19, having experienced compatible symptoms; however, only 208 (30.3%) of these were seropositive on both immunoassays. Both immunoassays had high sensitivities relative to previous PCR positivity (>93%); there was also limited decline in antibody titres up to 110 days post symptom onset. Symptomatic but seronegative individuals had differing symptom profiles and shorter illnesses than seropositive individuals.
Conclusion
Non-COVID-19 respiratory illness may have been mistaken for COVID-19 during the outbreak; laboratory testing is more specific than self-reported key worker beliefs in ascertaining past COVID-19 disease.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 (Disease) -- Diagnosis -- Great Britain, Immunoglobulins -- Diagnostic use, Serology | ||||||||
| Journal or Publication Title: | The Journal of infection | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 1532-2742 | ||||||||
| Official Date: | 1 May 2021 | ||||||||
| Dates: |
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| Volume: | 82 | ||||||||
| Number: | 5 | ||||||||
| Page Range: | pp. 151-161 | ||||||||
| DOI: | 10.1016/j.jinf.2021.03.019 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| RIOXX Funder/Project Grant: |
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