UNSPECIFIED (1998) DNA-drug systems: How circular dichroism data is complemented by other spectroscopic techniques. ENANTIOMER, 3 (4-5). pp. 395-408. ISSN 1024-2430

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Abstract

Circular dichroism (CD) measurements of DNA-drug complexes of two different systems are interpreted with the aid of other experimental and calculation data. The induced CD (ICD) of the polyamine mimic [Co(NH3)](3+) has been used to determine the low drug:DNA ratio binding constant with calf thymus DNA of 1,00,000 M-1 at 11 mM Na+. The site size is large. Linear dichroism (LD) shows how the DNA bends in accord with changes in DNA conformation observed in the CD. 9-hydroxyellipticine DNA binding in the intercalation limit and the higher concentration mode that gives rise to exciton CD signals have been probed using normal absorption, LD, both film and flow and resonance light scattering. CNDO/S-CI calculations have also been investigated as a means of determining transition moments and intensities of individual transitions in a complex overlapping spectrum.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	ENANTIOMER
Publisher:	GORDON BREACH SCI PUBL LTD
ISSN:	1024-2430
Date:	1998
Volume:	3
Number:	4-5
Number of Pages:	14
Page Range:	pp. 395-408
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/15106

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