The Library
Strengthening CoViD-19 therapy via combinations of RAS modulators.
Tools
Tools
Tools
Uzunova, Veselina V., Todev, Angel, Zarkos, Jacqueline, Addai, Daniel, Ananiev, Julian, Rashev, Pavel, Alexandrova, Radostina and Tolekova, Anna (2021) Strengthening CoViD-19 therapy via combinations of RAS modulators. Medical Hypotheses, 150 . 110571. doi:10.1016/j.mehy.2021.110571 ISSN 1532-2777.
|
PDF
1-s2.0-S030698772100089X-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (456Kb) | Preview |
Official URL: https://doi.org/10.1016/j.mehy.2021.110571
Abstract
Evidence has accumulated that the pathology of CoViD-19 is strongly related to the renin-angiotensin system (RAS). The blockage of the angiotensin converting enzyme 2 (ACE2) by the SARS-CoV-2 virus leads to downstream consequences such as increased vascular tone, extensive fibrosis and pronounced immune reactions. Different approaches to tackle the adverse viral effects by compensating the lost ACE2 function have been suggested. Here, we use an unequal-arm lever model to describe a simplified version of the biased regulation exercised by the angiotensin II and angiotensin-(1-7) hormones, which are the substrate and the product of ACE2, respectively. We reason upon the lever dynamics and its disruptions caused by the virus, and propose that a combination of RAS modulators will most efficiently compensate the imbalance due to the excess of angiotensin II and the scarcity of angiotensin-(1-7). Specifically, we focus on the possible benefits of the simultaneous application of two agents, a MAS-receptor agonist and an angiotensin-II-type-2-receptor agonist. We conjecture that this combination has the potential to introduce a beneficial synergistic action that promotes anti-hypoxic, anti-fibrotic and anti-proliferative effects, thereby improving the clinical management of acute and chronic CoViD-19 pathologies.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 (Disease) -- Treatment, COVID-19 (Disease) -- Prevention, Renin-angiotensin system, Renin | ||||||||
| Journal or Publication Title: | Medical Hypotheses | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 1532-2777 | ||||||||
| Official Date: | May 2021 | ||||||||
| Dates: |
|
||||||||
| Volume: | 150 | ||||||||
| Article Number: | 110571 | ||||||||
| DOI: | 10.1016/j.mehy.2021.110571 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 17 March 2022 | ||||||||
| Date of first compliant Open Access: | 17 March 2022 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
