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Seroprevalence of antibodies to SARS-CoV-2 among health care workers in Kenya

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Etyang, Anthony O., Lucinde, Ruth, Karanja, Henry, Kalu, Catherine, Mugo, Daisy, Nyagwange, James, Gitonga, John, Tuju, James, Wanjiku, Perpetual, Karani, Angela et al.
(2022) Seroprevalence of antibodies to SARS-CoV-2 among health care workers in Kenya. Clinical Infectious Diseases, 74 (2). pp. 288-293. doi:10.1093/cid/ciab346

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Official URL: https://doi.org/10.1093/cid/ciab346

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Abstract

Background
Few studies have assessed the seroprevalence of antibodies against SARS-CoV-2 among Health Care Workers (HCWs) in Africa. We report findings from a survey among HCWs in three counties in Kenya.

Methods
We recruited 684 HCWs from Kilifi (rural), Busia (rural) and Nairobi (urban) counties. The serosurvey was conducted between 30th July 2020 and 4th December 2020. We tested for IgG antibodies to SARS-CoV-2 spike protein using ELISA. Assay sensitivity and specificity were 93% (95% CI 88-96%) and 99% (95% CI 98-99.5%), respectively. We adjusted prevalence estimates using Bayesian modeling to account for assay performance.

Results
Crude overall seroprevalence was 19.7% (135/684). After adjustment for assay performance seroprevalence was 20.8% (95% CrI 17.5-24.4%). Seroprevalence varied significantly (p<0.001) by site: 43.8% (CrI 35.8-52.2%) in Nairobi, 12.6% (CrI 8.8-17.1%) in Busia and 11.5% (CrI 7.2-17.6%) in Kilifi. In a multivariable model controlling for age, sex and site, professional cadre was not associated with differences in seroprevalence.

Conclusion
These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): COVID-19 (Disease) , Medical personnel -- Kenya, Public health personnel -- Kenya, Epidemics -- Kenya, Immunoglobulins, Communicable diseases -- Immunological aspects
Journal or Publication Title: Clinical Infectious Diseases
Publisher: Oxford University Press
ISSN: 1058-4838
Official Date: January 2022
Dates:
DateEvent
January 2022Published
24 April 2021Available
15 April 2021Accepted
Volume: 74
Number: 2
Page Range: pp. 288-293
DOI: 10.1093/cid/ciab346
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
220991/Z/20/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
203077/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
INV-017547Bill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865
EARF/ITT/039East Africa Research FundUNSPECIFIED
MR/R006083/1Wellcome Trusthttp://dx.doi.org/10.13039/100010269
214320Wellcome Trusthttp://dx.doi.org/10.13039/100010269
MR/S005293/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
2268427 LSHTMGlobal Health Research Unit on Mucosal PathogensUNSPECIFIED
220985/Z/20/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
107568/Z/15/ZWellcome Trusthttp://dx.doi.org/10.13039/100010269
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