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Seroprevalence of antibodies to SARS-CoV-2 among health care workers in Kenya
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(2021) Seroprevalence of antibodies to SARS-CoV-2 among health care workers in Kenya. Clinical Infectious Diseases . doi:10.1093/cid/ciab346 (In Press)
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WRAP-Seroprevalence-antibodies-SARS-CoV-2-Health-care-workers-Kenya-2021.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1087Kb) | Preview |
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WRAP-seroprevalence-antibodies-SARS-CoV-2-among-health-care-workers-Kenya-Nokes-2021.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1035Kb) |
Official URL: https://doi.org/10.1093/cid/ciab346
Abstract
Background
Few studies have assessed the seroprevalence of antibodies against SARS-CoV-2 among Health Care Workers (HCWs) in Africa. We report findings from a survey among HCWs in three counties in Kenya.
Methods
We recruited 684 HCWs from Kilifi (rural), Busia (rural) and Nairobi (urban) counties. The serosurvey was conducted between 30th July 2020 and 4th December 2020. We tested for IgG antibodies to SARS-CoV-2 spike protein using ELISA. Assay sensitivity and specificity were 93% (95% CI 88-96%) and 99% (95% CI 98-99.5%), respectively. We adjusted prevalence estimates using Bayesian modeling to account for assay performance.
Results
Crude overall seroprevalence was 19.7% (135/684). After adjustment for assay performance seroprevalence was 20.8% (95% CrI 17.5-24.4%). Seroprevalence varied significantly (p<0.001) by site: 43.8% (CrI 35.8-52.2%) in Nairobi, 12.6% (CrI 8.8-17.1%) in Busia and 11.5% (CrI 7.2-17.6%) in Kilifi. In a multivariable model controlling for age, sex and site, professional cadre was not associated with differences in seroprevalence.
Conclusion
These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 (Disease) , Medical personnel -- Kenya, Public health personnel -- Kenya, Epidemics -- Kenya, Immunoglobulins, Communicable diseases -- Immunological aspects | |||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Clinical Infectious Diseases | |||||||||||||||||||||||||||||||||
| Publisher: | Oxford University Press | |||||||||||||||||||||||||||||||||
| ISSN: | 1058-4838 | |||||||||||||||||||||||||||||||||
| Official Date: | 24 April 2021 | |||||||||||||||||||||||||||||||||
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| DOI: | 10.1093/cid/ciab346 | |||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
| Publication Status: | In Press | |||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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