UNSPECIFIED (1998) Current status of HBV vaccine escape variants - a mathematical model of their epidemiology. JOURNAL OF VIRAL HEPATITIS, 5 (Suppl. 2). pp. 25-30.

Research output not available from this repository, contact author.

Request Changes to record.

Abstract

We present a deterministic model of the possible emergence of a vaccine escape variant of hepatitis B virus (HBV). The model identifies the key unknowns determining this process: the protection afforded by she current vaccines against particular HBV variants; the infectiousness of these variants; and the current prevalence of individuals infectious with the variants (each factor relative to wild-type). By malting pessimistic assumptions about these unknowns we show that even a highly infectious variant, under a vaccine programme that affords no protection against the variant, would still take decades to emerge. Thus the current low prevalence of variants is not evidence for the cross-reactivity of the current vaccines or for a lack of infectiousness in the variants. As any vaccine failure will be inapparent for decades it may be sensible to recommend vaccine modifications now rather than later.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF VIRAL HEPATITIS
Publisher:	BLACKWELL SCIENCE LTD
ISSN:	1352-0504
Official Date:	November 1998
Dates:	Date Event November 1998 UNSPECIFIED
Volume:	5
Number:	Suppl. 2
Number of Pages:	6
Page Range:	pp. 25-30
Publication Status:	Published

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item