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The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database

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Freeman, Karoline, Ryan, Ronan, Parsons, Nicholas R., Taylor-Phillips, Sian, Willis, Brian H. and Clarke, Aileen (2021) The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database. BMC Gastroenterology, 21 (1). 139. doi:10.1186/s12876-021-01716-6

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Official URL: http://dx.doi.org/10.1186/s12876-021-01716-6

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Abstract

Background:
Our knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases from general practice. Estimates are needed to inform health care providers who plan the provision of services for IBD patients. We aimed to estimate the IBD incidence and prevalence in UK general practice.

Methods:
We undertook a retrospective cohort study of routine electronic health records from the IQVIA Medical Research Database covering 14 million patients. Adult patients from 2006 to 2016 were included. IBD was defined as an IBD related Read code or record of IBD specific medication. Annual incidence and 12-month period prevalence were calculated.

Results:
The prevalence of IBD increased between 2006 and 2016 from 106.2 (95% CI 105.2–107.3) to 142.1 (95% CI 140.7–143.5) IBD cases per 10,000 patients which is a 33.8% increase. Incidence varied across the years. The incidence across the full study period was 69.5 (95% CI 68.6–70.4) per 100,000 person years.

Conclusions:
In this large study we found higher estimates of IBD incidence and prevalence than previously reported. Estimates are highly dependent on definitions of disease and previously may have been underestimated.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Inflammatory bowel diseases , Inflammatory bowel diseases -- Diagnosis
Journal or Publication Title: BMC Gastroenterology
Publisher: BioMed Central Ltd.
ISSN: 1471-230X
Official Date: 26 March 2021
Dates:
DateEvent
26 March 2021Published
10 March 2021Available
Volume: 21
Number: 1
Article Number: 139
DOI: 10.1186/s12876-021-01716-6
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
DRF-2016-09-038[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272

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