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Health-related quality of life from adolescence to adulthood following extremely preterm birth
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Ni, Yanyan, O'Reilly, Helen, Johnson, Samantha, Marlow, Neil and Wolke, Dieter (2021) Health-related quality of life from adolescence to adulthood following extremely preterm birth. The Journal of Pediatrics, 237 . 227-236.e5. doi:10.1016/j.jpeds.2021.04.005
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Official URL: https://doi.org/10.1016/j.jpeds.2021.04.005
Abstract
To examine self-reported and parent-reported health-related quality of life (HRQL) in adults born extremely preterm compared with term-born controls and to evaluate trajectories of health status from adolescence to early adulthood. The EPICure study comprises all births <26 weeks of gestation in the United Kingdom (UK) and Ireland in 1995 and term-born controls recruited at age 6. 129 participants born extremely preterm and 65 controls were followed up at the 19-year assessment. HRQL was measured by the Health Utilities Index Mark 3 (HUI3) multi-attribute utility (MAU) scores. Only parent-reported HRQL was available at 11 years of age. Participants born extremely preterm without neurodevelopmental impairment had significantly lower MAU scores at 19 years than controls (median [interquartile range]: 0.91 [0.79, 0.97] vs 0.97 [0.87, 1.00], p=0.008); those with impairment had the lowest scores (0.74 [0.49, 0.90]). A 0.03-0.05 difference is considered clinically significant. Parent-reported findings were similar. Participants born extremely preterm with impairment rated their health significantly better than their parents (0.74 vs 0.58, p=0.01), in contrast to those without impairment and controls. Between 11 and 19 years median parent-reported MAU scores decreased from 0.87 to 0.77 for participants born extremely preterm (p=0.01) and from 1.00 to 0.97 for controls (P = .02). Among young adults born extremely preterm, both participants and parents rated their health status less favorably than term-born controls. The decline in MAU scores from adolescence to early adulthood following extremely preterm birth indicates continuing health issues in young adult life. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]
| Item Type: | Journal Article | ||||||||||||||||||
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| Subjects: | H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Prematurely born children, Prematurely born children -- Growth, Premature infants -- Development, Premature infants -- Physiology , Quality of life | ||||||||||||||||||
| Journal or Publication Title: | The Journal of Pediatrics | ||||||||||||||||||
| Publisher: | Mosby, Inc. | ||||||||||||||||||
| ISSN: | 0022-3476 | ||||||||||||||||||
| Official Date: | October 2021 | ||||||||||||||||||
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| Volume: | 237 | ||||||||||||||||||
| Page Range: | 227-236.e5 | ||||||||||||||||||
| DOI: | 10.1016/j.jpeds.2021.04.005 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
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