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Health-related quality of life from adolescence to adulthood following extremely preterm birth

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Ni, Yanyan, O'Reilly, Helen, Johnson, Samantha, Marlow, Neil and Wolke, Dieter (2021) Health-related quality of life from adolescence to adulthood following extremely preterm birth. The Journal of Pediatrics, 237 . 227-236.e5. doi:10.1016/j.jpeds.2021.04.005

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Official URL: https://doi.org/10.1016/j.jpeds.2021.04.005

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Abstract

To examine self-reported and parent-reported health-related quality of life (HRQL) in adults born extremely preterm compared with term-born controls and to evaluate trajectories of health status from adolescence to early adulthood. The EPICure study comprises all births <26 weeks of gestation in the United Kingdom (UK) and Ireland in 1995 and term-born controls recruited at age 6. 129 participants born extremely preterm and 65 controls were followed up at the 19-year assessment. HRQL was measured by the Health Utilities Index Mark 3 (HUI3) multi-attribute utility (MAU) scores. Only parent-reported HRQL was available at 11 years of age. Participants born extremely preterm without neurodevelopmental impairment had significantly lower MAU scores at 19 years than controls (median [interquartile range]: 0.91 [0.79, 0.97] vs 0.97 [0.87, 1.00], p=0.008); those with impairment had the lowest scores (0.74 [0.49, 0.90]). A 0.03-0.05 difference is considered clinically significant. Parent-reported findings were similar. Participants born extremely preterm with impairment rated their health significantly better than their parents (0.74 vs 0.58, p=0.01), in contrast to those without impairment and controls. Between 11 and 19 years median parent-reported MAU scores decreased from 0.87 to 0.77 for participants born extremely preterm (p=0.01) and from 1.00 to 0.97 for controls (P = .02). Among young adults born extremely preterm, both participants and parents rated their health status less favorably than term-born controls. The decline in MAU scores from adolescence to early adulthood following extremely preterm birth indicates continuing health issues in young adult life. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]

Item Type: Journal Article
Subjects: H Social Sciences > HN Social history and conditions. Social problems. Social reform
R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Science > Psychology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Prematurely born children, Prematurely born children -- Growth, Premature infants -- Development, Premature infants -- Physiology , Quality of life
Journal or Publication Title: The Journal of Pediatrics
Publisher: Mosby, Inc.
ISSN: 0022-3476
Official Date: October 2021
Dates:
DateEvent
October 2021Published
7 April 2021Available
2 April 2021Accepted
Volume: 237
Page Range: 227-236.e5
DOI: 10.1016/j.jpeds.2021.04.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
MR/J01107X/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDDepartment of Health, Social Services and Public Safety, UK GovernmentUNSPECIFIED
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
733280Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661
Norface Network Dial program (462-16-040)Horizon 2020 Framework Programmehttp://dx.doi.org/10.13039/100010661

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