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The orbitofrontal cortex, food reward, body weight and obesity
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Rolls, Edmund T. (2021) The orbitofrontal cortex, food reward, body weight and obesity. Social Cognitive and Affective Neuroscience . doi:10.1093/scan/nsab044 (In Press)
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WRAP-orbitofrontal-cortex-food-reward-body-weight-obesity-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2106Kb) | Preview |
Official URL: https://doi.org/10.1093/scan/nsab044
Abstract
In primates including humans, the orbitofrontal cortex is the key brain region representing the reward value and subjective pleasantness of the sight, smell, taste and texture of food. At stages of processing before this, in the insular taste cortex and inferior temporal visual cortex, the identity of the food is represented, but not its affective value. In rodents, the whole organisation of reward systems appears to be different, with reward value reflected earlier in processing systems. In primates and humans, the amygdala is overshadowed by the great development of the orbitofrontal cortex. Social and cognitive factors exert a top-down influence on the orbitofrontal cortex, to modulate the reward value of food that is represented in the orbitofrontal cortex. Recent evidence shows that even in the resting state, with no food present as a stimulus, the liking for food, and probably as a consequence of that body mass index, is correlated with the functional connectivity of the orbitofrontal cortex and ventromedial prefrontal cortex. This suggests that individual differences in these orbitofrontal cortex reward systems contribute to individual differences in food pleasantness and obesity. Implications of how these reward systems in the brain operate for understanding, preventing and treating obesity are described.
| Item Type: | Journal Article | ||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Food -- Psychological aspects, Prefrontal cortex, Reward (Psychology), Taste, Smell, Obesity -- Prevention, Cognitive psychology | ||||||
| Journal or Publication Title: | Social Cognitive and Affective Neuroscience | ||||||
| Publisher: | Oxford University Press (OUP) | ||||||
| ISSN: | 1749-5024 | ||||||
| Official Date: | 8 April 2021 | ||||||
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| DOI: | 10.1093/scan/nsab044 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | In Press | ||||||
| Access rights to Published version: | Open Access | ||||||
| RIOXX Funder/Project Grant: |
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