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The orbitofrontal cortex, food reward, body weight and obesity

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Rolls, Edmund T. (2021) The orbitofrontal cortex, food reward, body weight and obesity. Social Cognitive and Affective Neuroscience . doi:10.1093/scan/nsab044 (In Press)

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Official URL: https://doi.org/10.1093/scan/nsab044

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Abstract

In primates including humans, the orbitofrontal cortex is the key brain region representing the reward value and subjective pleasantness of the sight, smell, taste and texture of food. At stages of processing before this, in the insular taste cortex and inferior temporal visual cortex, the identity of the food is represented, but not its affective value. In rodents, the whole organisation of reward systems appears to be different, with reward value reflected earlier in processing systems. In primates and humans, the amygdala is overshadowed by the great development of the orbitofrontal cortex. Social and cognitive factors exert a top-down influence on the orbitofrontal cortex, to modulate the reward value of food that is represented in the orbitofrontal cortex. Recent evidence shows that even in the resting state, with no food present as a stimulus, the liking for food, and probably as a consequence of that body mass index, is correlated with the functional connectivity of the orbitofrontal cortex and ventromedial prefrontal cortex. This suggests that individual differences in these orbitofrontal cortex reward systems contribute to individual differences in food pleasantness and obesity. Implications of how these reward systems in the brain operate for understanding, preventing and treating obesity are described.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Science > Computer Science
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Food -- Psychological aspects, Prefrontal cortex, Reward (Psychology), Taste, Smell, Obesity -- Prevention, Cognitive psychology
Journal or Publication Title: Social Cognitive and Affective Neuroscience
Publisher: Oxford University Press (OUP)
ISSN: 1749-5024
Official Date: 8 April 2021
Dates:
DateEvent
8 April 2021Published
8 April 2021Accepted
DOI: 10.1093/scan/nsab044
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
Related URLs:
  • http://creativecommons.org/licenses/by/4...

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