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Biochemical abnormalities in COVID-19 : a comparison of white versus ethnic minority populations in the UK
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Taylor, David R., Buchanan, Devon, Mazaheri , Tina, Kearney, Jessica, Ranasinghe, Ruvini N. K., Dimitriadis, Georgios K. and Vincent, Royce P. (2022) Biochemical abnormalities in COVID-19 : a comparison of white versus ethnic minority populations in the UK. Journal of Clinical Pathology, 75 (10). pp. 663-667. doi:10.1136/jclinpath-2021-207446 ISSN 0021-9746.
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WRAP-biochemical-abnormalities-coronavirus-disease-2019-(COVID-19)-comparison-White-vs.-ethnic-minority-populations-U.K-Dimitriadis-2021.pdf - Accepted Version - Requires a PDF viewer. Download (720Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/jclinpath-2021-207446
Abstract
Aims: Public Health England has identified that in COVID-19, death rates among ethnic minorities far exceeds that of the white population. While the increase in ethnic minorities is likely to be multifactorial, to date, no studies have looked to see whether values for routine clinical biochemistry parameters differ between ethnic minority and white individuals.
Methods: Baseline biochemical data for 22 common tests from 311 SARS-CoV-2 positive patients presenting to hospital in April 2020 in whom ethnicity data were available was retrospectively collected and evaluated. Data comparisons between ethnic minority and white groups were made for all patient data and for the subset of patients subsequently admitted to intensive care.
Results: When all patient data were considered, the ethnic minority population had statistically significant higher concentrations of C reactive protein (CRP), aspartate aminotransferase and gamma-glutamyl transferase, while troponin T was higher in the white group. A greater proportion of ethnic minority patients were subsequently admitted to intensive care, but when the presenting biochemistry of this subset of patients was compared, no significant differences were observed between ethnic minority and white groups.
Conclusion: Our data show for the first time that routine biochemistry at hospital presentation in COVID-19 differs between ethnic minority and white groups. Among the markers identified, CRP was significantly higher in the ethnic minority group pointing towards an increased tendency for severe inflammation in this group.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | COVID-19 (Disease), Minorities -- Health and hygiene, Ethnicity -- Health aspects -- Research, Biochemical markers -- Research | ||||||||
Journal or Publication Title: | Journal of Clinical Pathology | ||||||||
Publisher: | B M J Group | ||||||||
ISSN: | 0021-9746 | ||||||||
Official Date: | 19 September 2022 | ||||||||
Dates: |
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Volume: | 75 | ||||||||
Number: | 10 | ||||||||
Page Range: | pp. 663-667 | ||||||||
DOI: | 10.1136/jclinpath-2021-207446 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | This article has been accepted for publication in Journal of Clinical Pathology, 2021 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/jclinpath-2021-207446 © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Description: | Free COVID article |
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Date of first compliant deposit: | 6 May 2021 | ||||||||
Date of first compliant Open Access: | 4 June 2021 | ||||||||
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