Song, Qiao, Cheng, Zihe, Kariuki, Maria, Hall, Stephen C. L., Hill, Sophie K., Rho, Julia Y. and Perrier, Sébastien (2021) Molecular self-assembly and supramolecular chemistry of cyclic peptides. Chemical Reviews, 121 (22). pp. 13936-13995. doi:10.1021/acs.chemrev.0c01291 ISSN 0009-2665.

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Abstract

This Review focuses on the establishment and development of self-assemblies governed by the supramolecular interactions between cyclic peptides. The Review first describes the type of cyclic peptides able to assemble into tubular structures to form supramolecular cyclic peptide nanotubes. A range of cyclic peptides have been identified to have such properties, including α-peptides, β-peptides, α,γ-peptides, and peptides based on δ- and ε-amino acids. The Review covers the design and functionalization of these cyclic peptides and expands to a recent advance in the design and application of these materials through their conjugation to polymer chains to generate cyclic peptide–polymer conjugates nanostructures. The Review, then, concentrates on the challenges in characterizing these systems and presents an overview of the various analytical and characterization techniques used to date. This overview concludes with a critical survey of the various applications of the nanomaterials obtained from supramolecular cyclic peptide nanotubes, with a focus on biological and medical applications, ranging from ion channels and membrane insertion to antibacterial materials, anticancer drug delivery, gene delivery, and antiviral applications.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Polymers, Supramolecular chemistry, Cyclic peptides -- Synthesis, Self-assembly (Chemistry)
Journal or Publication Title:	Chemical Reviews
Publisher:	American Chemical Society
ISSN:	0009-2665
Official Date:	24 November 2021
Dates:	Date Event 24 November 2021 Published 3 May 2021 Available 3 May 2021 Accepted
Volume:	121
Number:	22
Page Range:	pp. 13936-13995
DOI:	10.1021/acs.chemrev.0c01291
Status:	Peer Reviewed
Publication Status:	Published
Reuse Statement (publisher, data, author rights):	“This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Reviews, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].”
Access rights to Published version:	Open Access (Creative Commons)
Copyright Holders:	© 2021 American Chemical Society
Date of first compliant deposit:	7 May 2021
Date of first compliant Open Access:	4 March 2022
RIOXX Funder/Project Grant:	Project/Grant ID RIOXX Funder Name Funder ID TUSUPO 647106 European Research Council http://dx.doi.org/10.13039/501100000781 UNSPECIFIED [EPSRC] Engineering and Physical Sciences Research Council http://dx.doi.org/10.13039/501100000266 UNSPECIFIED AstraZeneca http://dx.doi.org/10.13039/100004325 UNSPECIFIED Molecular Analytical Science Centre for Doctoral Training UNSPECIFIED

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