Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Molecular identification and cellular localisation of a corticotropin-releasing hormone type neuropeptide in an echinoderm

Tools
- Tools
+ Tools

Cai, Weigang, Egertová, Michaela, Zampronio, Cleidiane G., Jones, Alexandra M. and Elphick, Maurice R. (2023) Molecular identification and cellular localisation of a corticotropin-releasing hormone type neuropeptide in an echinoderm. Neuroendocrinology, 113 (2). pp. 231-250. doi:10.1159/000517087 ISSN 0028-3835.

[img]
Preview
PDF
WRAP-corticotropin-releasing-hormone-type-neuropeptide-echinoderm-Jones-2021.pdf - Accepted Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (3271Kb) | Preview
Official URL: http://dx.doi.org/10.1159/000517087

Request Changes to record.

Abstract

Background: Corticotropin-releasing hormone (CRH) mediates physiological responses to stressors in mammals by triggering pituitary secretion of adrenocorticotropic hormone, which stimulates adrenal release of cortisol. CRH belongs to a family of related neuropeptides that include sauvagine, urotensin-I and urocortins in vertebrates and the diuretic hormone DH44 in insects, indicating that the evolutionary origin of this neuropeptide family can be traced to the common ancestor of the Bilateria. However, little is known about CRH-type neuropeptides in deuterostome invertebrates. Methods: Here we used mass spectrometry, mRNA in situ hybridization and immunohistochemistry to investigate the structure and expression of a CRH-type neuropeptide (ArCRH) in the starfish Asterias rubens (phylum Echinodermata). Results: ArCRH is a 40-residue peptide with N-terminal pyroglutamylation and C-terminal amidation and it has a widespread pattern of expression in A. rubens. In the central nervous system comprising the circumoral nerve ring and five radial nerve cords, ArCRH-expressing cells and fibres were revealed in both the ectoneural region and the hyponeural region, which contains the cell bodies of motoneurons. Accordingly, ArCRH-immunoreactivity was detected in innervation of the ampulla and podium of locomotory organs (tube feet), and ArCRH is the first neuropeptide to be identified as a marker for nerve fibres located in the muscle layer of these organs. ArCRH-immunoreactivity was also revealed in protractile organs that mediate gas exchange (papulae), the apical muscle and the digestive system. Conclusions: Our findings provide the first insights into CRH-type neuropeptide expression and function in the unique context of the pentaradially symmetrical body plan of an echinoderm.

Item Type: Journal Article
Subjects: Q Science > QL Zoology
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Corticotropin releasing hormone , Corticotropin releasing hormone -- Classification -- Molecular aspects, Neuropeptides , Echinodermata , Echinodermata -- Physiology
Journal or Publication Title: Neuroendocrinology
Publisher: Karger
ISSN: 0028-3835
Official Date: February 2023
Dates:
DateEvent
February 2023Published
7 May 2021Available
30 April 2021Accepted
Volume: 113
Number: 2
Page Range: pp. 231-250
DOI: 10.1159/000517087
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 17 May 2021
Date of first compliant Open Access: 18 May 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDChina Scholarship Councilhttp://dx.doi.org/10.13039/501100004543
BB/M001644/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/M001032/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us