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Evolutionarily ancient role of cholecystokinin-type neuropeptide signalling as an inhibitory regulator of feeding-related processes revealed in an echinoderm [pre-print]
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Tinoco, Ana B., Barreiro-Iglesias, Antón, Yañez-Guerra, Luis Alfonso, Delroisse, Jérôme, Zhang, Ya, Gunner, Elizabeth F., Zampronio, Cleidiane, Jones, Alexandra M., Egertová, Michaela and Elphick, Maurice R. (2020) Evolutionarily ancient role of cholecystokinin-type neuropeptide signalling as an inhibitory regulator of feeding-related processes revealed in an echinoderm [pre-print]. Working Paper. Cold Spring Harbor, New York: bioRxiv. (Unpublished)
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Official URL: http://dx.doi.org/10.1101/2020.12.11.417543
Abstract
Cholecystokinin (CCK) / sulfakinin (SK)-type neuropeptides regulate feeding and digestion in chordates and protostomes (e.g. insects). Here we characterised CCK/SK-type signalling for the first time in a non-chordate deuterostome - the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArCCK1, ArCCK2) derived from the precursor protein ArCCKP act as ligands for a CCK/SK-type receptor (ArCCKR) and are expressed in the nervous system, digestive system, tube feet and body wall. Furthermore, ArCCK1 and ArCCK2 cause dose-dependent contraction of cardiac stomach, tube foot and body wall apical muscle preparations in vitro and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of CCK/SK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.
Item Type: | Working or Discussion Paper (Working Paper) | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Publisher: | bioRxiv | ||||
Place of Publication: | Cold Spring Harbor, New York | ||||
Official Date: | 11 December 2020 | ||||
Dates: |
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DOI: | 10.1101/2020.12.11.417543 | ||||
Institution: | University of Warwick | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Unpublished | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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