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A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA
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Li, Chun-Yang, Wang, Xiu-Juan, Chen, Xiu-Lan, Sheng, Qi, Zhang, Shan, Wang, Peng, Quareshy, Mussa, Rihtman, Branko, Shao, Xuan, Gao, Chao, Li, Fuchuan, Li, Shengying, Zhang, Weipeng, Zhang, Xiao-Hua, Yang, Gui-Peng, Todd, Jonathan D., Chen, Yin and Zhang, Yu-Zhong (2021) A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA. eLife, 10 . e64045. doi:10.7554/eLife.64045 ISSN 2050-084X.
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WRAP-novel-ATP-dependent-dimethylsulfoniopropionate-lyase-bacteria-Chen-2021.pdf - Accepted Version - Requires a PDF viewer. Download (5Mb) | Preview |
Official URL: http://dx.doi.org/10.7554/eLife.64045
Abstract
Dimethylsulfoniopropionate (DMSP) is an abundant and ubiquitous organosulfur molecule in marine environments with important roles in global sulfur and nutrient cycling. Diverse DMSP lyases in some algae, bacteria and fungi cleave DMSP to yield gaseous dimethyl sulfide (DMS), an infochemical with important roles in atmospheric chemistry. Here we identified a novel ATP-dependent DMSP lyase, DddX. DddX belongs to the acyl-CoA synthetase superfamily and is distinct from the eight other known DMSP lyases. DddX catalyses the conversion of DMSP to DMS via a two-step reaction: the ligation of DMSP with CoA to form the intermediate DMSP-CoA, which is then cleaved to DMS and acryloyl-CoA. The novel catalytic mechanism was elucidated by structural and biochemical analyses. DddX is found in several Alphaproteobacteria, Gammaproteobacteria and Firmicutes, suggesting that this new DMSP lyase may play an overlooked role in DMSP/DMS cycles.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QC Physics Q Science > QK Botany Q Science > QP Physiology T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Dimethylpropiothetin, Marine biotechnology , Atmospheric dimethyl sulfide , Adenosine triphosphate -- Synthesis | ||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | eLife | ||||||||||||||||||||||||||||||||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||||||||||||||||||||||||||||||||
| ISSN: | 2050-084X | ||||||||||||||||||||||||||||||||||||
| Official Date: | 10 May 2021 | ||||||||||||||||||||||||||||||||||||
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| Volume: | 10 | ||||||||||||||||||||||||||||||||||||
| Article Number: | e64045 | ||||||||||||||||||||||||||||||||||||
| DOI: | 10.7554/eLife.64045 | ||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 11 May 2021 | ||||||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 12 May 2021 | ||||||||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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| Is Part Of: | 1 |
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