UNSPECIFIED (1998) Microparasite population dynamics and continuous immunity. PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 265 (1409). pp. 1977-1983. ISSN 0962-8452

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Abstract

A mathematical model is presented for the transmission of a microparasite where the hosts occupy one of two states, uninfected or infected. In each state, the hosts are distributed over a continuous range of immunity. The immune levels vary within hosts due to the processes of waning of immunity (when uninfected), and increasing immunity (when infected), eventually resulting in recovery. Immunity level also influences the host's ability to infect or be infected. Thus the proposed model incorporates both inter- and intra-host dynamics. It is shown from equilibrium results that this model is a general form of the susceptible-infected-resistant (SIR) and susceptible-infected-susceptible (SIS) family of models, a development that is useful for exploring multistrain pathogen transmission and use of vaccines which confer temporary protection.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Publisher:	ROYAL SOC LONDON
ISSN:	0962-8452
Date:	22 October 1998
Volume:	265
Number:	1409
Number of Pages:	7
Page Range:	pp. 1977-1983
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/15235

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