The Library
Attractor cortical neurodynamics, schizophrenia, and depression
Tools
Rolls, Edmund T. (2021) Attractor cortical neurodynamics, schizophrenia, and depression. Translational Psychiatry, 11 (1). 215. doi:10.1038/s41398-021-01333-7 ISSN 2158-3188.
|
PDF
WRAP-Attractor-cortical-neurodynamics-schizophrenia-depression-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1674Kb) | Preview |
Official URL: https://doi.org/10.1038/s41398-021-01333-7
Abstract
The local recurrent collateral connections between cortical neurons provide a basis for attractor neural networks for memory, attention, decision-making, and thereby for many aspects of human behavior. In schizophrenia, a reduction of the firing rates of cortical neurons, caused for example by reduced NMDA receptor function or reduced spines on neurons, can lead to instability of the high firing rate attractor states that normally implement short-term memory and attention in the prefrontal cortex, contributing to the cognitive symptoms. Reduced NMDA receptor function in the orbitofrontal cortex by reducing firing rates may produce negative symptoms, by reducing reward, motivation, and emotion. Reduced functional connectivity between some brain regions increases the temporal variability of the functional connectivity, contributing to the reduced stability and more loosely associative thoughts. Further, the forward projections have decreased functional connectivity relative to the back projections in schizophrenia, and this may reduce the effects of external bottom-up inputs from the world relative to internal top-down thought processes. Reduced cortical inhibition, caused by a reduction of GABA neurotransmission, can lead to instability of the spontaneous firing states of cortical networks, leading to a noise-induced jump to a high firing rate attractor state even in the absence of external inputs, contributing to the positive symptoms of schizophrenia. In depression, the lateral orbitofrontal cortex non-reward attractor network system is over-connected and has increased sensitivity to non-reward, providing a new approach to understanding depression. This is complemented by under-sensitivity and under-connectedness of the medial orbitofrontal cortex reward system in depression.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Computational neuroscience , Neural networks (Neurobiology), Schizophrenia -- Computer simulation, Schizophrenia -- Pathophysiology, Brain -- Localization of functions, Methyl aspartate -- Receptors | ||||||
Journal or Publication Title: | Translational Psychiatry | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 2158-3188 | ||||||
Official Date: | 12 April 2021 | ||||||
Dates: |
|
||||||
Volume: | 11 | ||||||
Number: | 1 | ||||||
Article Number: | 215 | ||||||
DOI: | 10.1038/s41398-021-01333-7 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 20 September 2021 | ||||||
Date of first compliant Open Access: | 20 September 2021 | ||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year