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COVID-19 in people with schizophrenia : potential mechanisms linking schizophrenia to poor prognosis

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Mohan, Mohapradeep, Perry, Benjamin Ian, Saravanan, Ponnusamy and Singh, Swaran P. (2021) COVID-19 in people with schizophrenia : potential mechanisms linking schizophrenia to poor prognosis. Frontiers in Psychiatry, 12 . doi:10.3389/fpsyt.2021.666067 ISSN 1664-0640.

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Official URL: http://dx.doi.org/10.3389/fpsyt.2021.666067

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Abstract

As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Schizophrenia, COVID-19 (Disease), Mental illness, COVID-19 (Disease) -- Psychological aspects, Epidemics -- Psychological aspects, Mental health
Journal or Publication Title: Frontiers in Psychiatry
Publisher: Frontiers Research Foundation
ISSN: 1664-0640
Official Date: 17 June 2021
Dates:
DateEvent
17 June 2021Published
15 April 2021Accepted
Volume: 12
DOI: 10.3389/fpsyt.2021.666067
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 19 May 2021
Date of first compliant Open Access: 20 May 2021
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
16/137/107[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
DRF-2018-11-ST2-018[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
MR/R020981/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
Is Part Of: 1

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