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COVID-19 in people with schizophrenia : potential mechanisms linking schizophrenia to poor prognosis
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Mohan, Mohapradeep, Perry, Benjamin Ian, Saravanan, Ponnusamy and Singh, Swaran P. (2021) COVID-19 in people with schizophrenia : potential mechanisms linking schizophrenia to poor prognosis. Frontiers in Psychiatry, 12 . doi:10.3389/fpsyt.2021.666067 ISSN 1664-0640.
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WRAP-COVID-19-people-schizophrenia-mechanisms-prognosis-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (642Kb) | Preview |
Official URL: http://dx.doi.org/10.3389/fpsyt.2021.666067
Abstract
As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Schizophrenia, COVID-19 (Disease), Mental illness, COVID-19 (Disease) -- Psychological aspects, Epidemics -- Psychological aspects, Mental health | ||||||||||||
| Journal or Publication Title: | Frontiers in Psychiatry | ||||||||||||
| Publisher: | Frontiers Research Foundation | ||||||||||||
| ISSN: | 1664-0640 | ||||||||||||
| Official Date: | 17 June 2021 | ||||||||||||
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| Volume: | 12 | ||||||||||||
| DOI: | 10.3389/fpsyt.2021.666067 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 19 May 2021 | ||||||||||||
| Date of first compliant Open Access: | 20 May 2021 | ||||||||||||
| RIOXX Funder/Project Grant: |
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| Is Part Of: | 1 |
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