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The human gut phageome : origins and roles in the human gut microbiome
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Townsend, Eleanor, Kelly, Lucy, Muscatt, George, Box, Joshua D., Hargraves, Nicole, Lilley, Daniel and Jameson, Eleanor (2021) The human gut phageome : origins and roles in the human gut microbiome. Frontiers in Cellular and Infection Microbiology, 11 . 643214. doi:10.3389/fcimb.2021.643214 ISSN 2235-2988.
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Official URL: https://doi.org/10.3389/fcimb.2021.643214
Abstract
The investigation of the microbial populations of the human body, known as the microbiome, has led to a revolutionary field of science, and understanding of its impacts on human development and health. The majority of microbiome research to date has focussed on bacteria and other kingdoms of life, such as fungi. Trailing behind these is the interrogation of the gut viruses, specifically the phageome. Bacteriophages, viruses that infect bacterial hosts, are known to dictate the dynamics and diversity of bacterial populations in a number of ecosystems. However, the phageome of the human gut, while of apparent importance, remains an area of many unknowns. In this paper we discuss the role of bacteriophages within the human gut microbiome. We examine the methods used to study bacteriophage populations, how this evolved over time and what we now understand about the phageome. We review the phageome development in infancy, and factors that may influence phage populations in adult life. The role and action of the phageome is then discussed at both a biological-level, and in the broader context of human health and disease.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Intestines -- Microbiology, Intestines -- Diseases, Bacteriophages, Microbial genomics | |||||||||
Journal or Publication Title: | Frontiers in Cellular and Infection Microbiology | |||||||||
Publisher: | Frontiers Media | |||||||||
ISSN: | 2235-2988 | |||||||||
Official Date: | 4 June 2021 | |||||||||
Dates: |
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Volume: | 11 | |||||||||
Article Number: | 643214 | |||||||||
DOI: | 10.3389/fcimb.2021.643214 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 2 June 2021 | |||||||||
Date of first compliant Open Access: | 9 June 2021 | |||||||||
Funder: | Funded by WISB BBSRC/EPSRC grant ref: BB/M017982/1 under the UK Research Councils’ Synthetic 2224 Biology for Growth programme. The work has also been supported by PhD fellowships awarded to LK, GM, and JB 2226 through DTPs funded by BBSRC, EPSRC and NERC | |||||||||
RIOXX Funder/Project Grant: |
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