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Aberrant cortico-thalamic structural connectivity in premature-born adults

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Menegaux, Aurore, Meng, Chun, Bäuml, Josef G., Berndt, Maria T., Hedderich, Dennis M., Schmitz-Koep, Benita, Schneider, Sebastian C., Nuttall, Rachel, Zimmermann, Juliana, Daamen, Marcel, Zimmer, Claus, Boecker, Henning, Bartmann, Peter, Wolke, Dieter and Sorg, Christian (2021) Aberrant cortico-thalamic structural connectivity in premature-born adults. Cortex, 141 . pp. 347-362. doi:10.1016/j.cortex.2021.04.009

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Official URL: http://dx.doi.org/10.1016/j.cortex.2021.04.009

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Abstract

Premature birth is associated with alterations in brain structure, particularly in white matter. Among white matter, alterations in cortico-thalamic connections are present in premature-born infants, and they have been suggested both to last until adulthood and to contribute to impaired cognitive functions. To test these hypotheses, 70 very premature-born adults and 67 full-term controls underwent cognitive testing and diffusion-weighted imaging. Each cortical hemisphere was parcellated into six lobes, from which probabilistic tractography was performed to the thalamus. Connection probability was chosen as metric of structural connectivity. We found increased cortico-thalamic connection probability between left prefrontal cortices and left medio-dorsal thalamus and reduced connection probability between bilateral temporal cortices and bilateral anterior thalami in very premature-born adults. Aberrant prefronto- and temporo-thalamic connection probabilities were correlated with birth weight and days on ventilation, respectively, supporting the suggestion that these connectivity changes relate with the degree of prematurity. Moreover, an increase in left prefronto-thalamic connection probability also correlated with lower verbal comprehension index indicating its relevance for verbal cognition. Together, our results demonstrate that cortico-thalamic structural connectivity is aberrant in premature-born adults, with these changes being linked with impairments in verbal cognitive abilities. Due to corresponding findings in infants, data suggest aberrant development of cortico-thalamic connectivity after premature birth with lasting effects into adulthood.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RJ Pediatrics
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Science > Psychology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Premature infants, Premature infants -- Development, White matter , Brain -- Evolution, Cognition disorders , Brain -- Abnormalities
Journal or Publication Title: Cortex
Publisher: Elsevier Masson
ISSN: 0010-9452
Official Date: August 2021
Dates:
DateEvent
August 2021Published
8 May 2021Available
26 April 2021Accepted
Volume: 141
Page Range: pp. 347-362
DOI: 10.1016/j.cortex.2021.04.009
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
SO 1336/1-1 [DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
BMBF 01ER0801Bundesministerium für Bildung, Wissenschaft, Forschung und Technologiehttp://dx.doi.org/10.13039/501100010571
BMBF 01ER0803Bundesministerium für Bildung, Wissenschaft, Forschung und Technologiehttp://dx.doi.org/10.13039/501100010571
KKF 8765162 Technische Universität Münchenhttp://dx.doi.org/10.13039/501100005713
KKF8700000474 Technische Universität Münchenhttp://dx.doi.org/10.13039/501100005713

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