The Library
Type 2 diabetes mellitus, glycaemic control, associated therapies and risk of rheumatoid arthritis : a retrospective cohort study
Tools
Tools
Tools
Zemedikun, Dawit T., Gokhale, Krishna, Chandan, Joht Singh, Cooper, Jennifer, Lord, Janet M., Filer, Andrew, Falahee, Marie, Nirantharakumar, Krishnarajah and Raza, Karim (2021) Type 2 diabetes mellitus, glycaemic control, associated therapies and risk of rheumatoid arthritis : a retrospective cohort study. Rheumatology, 60 (12). pp. 5567-5575. doi:10.1093/rheumatology/keab148 ISSN 1462-0332.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1093/rheumatology/keab148
Abstract
Objective . To compare the incident risk of RA in patients with type 2 diabetes mellitus (T2DM) and to explore the role of glycaemic control and associated therapeutic use in the onset of RA. Methods . This study was a retrospective cohort study using patients derived from the IQVIA Medical Research Data (IMRD-UK) database between 1995 and 2019. A total of 224 551 newly diagnosed patients with T2DM were matched to 449 101 patients without T2DM and followed up to assess their risk of RA. Further analyses investigated the effect of glycaemic control, statin use and anti-diabetic drugs on the relationship between T2DM and RA using a time-dependent Cox regression model. Results . During the study period, the incidence of RA was 8.1 and 10.6 per 10 000 person-years in the exposed and unexposed groups, respectively. The adjusted hazard ratio (aHR) was 0.73 (95% CI 0.67, 0.79). In patients who had not used statins in their lifetime, the aHR was 0.89 (95% CI 0.69, 1.14). When quantifying the effects of glycaemic control, anti-diabetic drugs and statins using time-varying analyses, there was no association with glycaemic control [aHR 1.00 (95% CI 0.99, 1.00)], use of metformin [aHR 1.00 (95% CI 0.82, 1.22)], dipeptidyl peptidase-4 inhibitors [DPP4is; aHR 0.94 (95% CI 0.71, 1.24)] and the development of RA. However, statins demonstrated a protective effect for progression of RA in those with T2DM [aHR 0.76 (95% CI 0.66, 0.88)], with evidence of a duration–response relationship. Conclusion . There is a reduced risk of RA in patients with T2DM that may be attributable to the use of statins.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Journal or Publication Title: | Rheumatology | ||||||||
| Publisher: | Oxford University Press (OUP) | ||||||||
| ISSN: | 1462-0332 | ||||||||
| Official Date: | December 2021 | ||||||||
| Dates: |
|
||||||||
| Volume: | 60 | ||||||||
| Number: | 12 | ||||||||
| Page Range: | pp. 5567-5575 | ||||||||
| DOI: | 10.1093/rheumatology/keab148 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | ** Article version: AM ** From Crossref journal articles via Jisc Publications Router ** History: epub 16-02-2021; issued 16-02-2021. ** Licence for AM version of this article starting on 16-02-2021: http://creativecommons.org/licenses/by/4.0/ | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
