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Effects of insoluble cereal fibre on body fat distribution in the optimal fibre trial
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Kabisch, Stefan, Honsek, Caroline, Kemper, Margrit, Gerbracht, Christiana, Meyer, Nina Marie Tosca, Arafat, Ayman M., Birkenfeld, Andreas L., Machann, Jürgen, Dambeck, Ulrike, Osterhoff, Martin A., Weickert, Martin O. and Pfeiffer, Andreas F. H. (2021) Effects of insoluble cereal fibre on body fat distribution in the optimal fibre trial. Molecular Nutrition & Food Research, 65 (12). 2000991. doi:10.1002/mnfr.202000991 ISSN 1613-4133.
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WRAP-effects-insoluble-cereal-fibre-bodyfat-distribution-optimal-fibre-tria-Weickert-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (230Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/mnfr.202000991
Abstract
Scope:
The Optimal Fibre Trial (OptiFiT) investigates metabolic effects of insoluble cereal fibre in subjects with impaired glucose tolerance (IGT), showing moderate glycemic and anti-inflammatory benefits, especially in subjects with an obesity-related phenotype. An OptiFiT sub-group is analysed for effects on body fat distribution.
Methods and results:
180 participants with IGT receive a blinded, randomized supplementation with insoluble cereal fibre or placebo for 2 years. Once a year, all subjects undergo fasting blood sampling, oral glucose tolerance test, and anthropometric measurements. A subgroup (n=47) also received magnetic resonance imaging and spectroscopy for quantification of adipose tissue distribution and liver fat content. We compared MR, metabolic and inflammatory outcomes between fibre and placebo group metabolism and inflammation.
Visceral and non-visceral fat, fasting glucose, HbA1c, fasting insulin, insulin resistance, and uric acid decrease only in the fibre group, mirroring effects of the entire cohort. However, after adjustment for weight loss, there are no significant between-group differences. There is a statistical trend for fibre-driven liver fat reduction in subjects with confirmed non-alcoholic fatty liver disease (NAFLD; n = 19).
Conclusions:
Data and evidence on beneficial effects of insoluble cereal fibre on visceral and hepatic fatstorage is limited, but warrants further research. Targeted trials are required.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Fiber in human nutrition , Blood sugar, Glucose, Non-insulin-dependent diabetes , Non-insulin-dependent diabetes -- Prevention , Food -- Fiber content -- Analysis, Prediabetic state | ||||||
Journal or Publication Title: | Molecular Nutrition & Food Research | ||||||
Publisher: | Wiley | ||||||
ISSN: | 1613-4133 | ||||||
Official Date: | 23 June 2021 | ||||||
Dates: |
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Volume: | 65 | ||||||
Number: | 12 | ||||||
Article Number: | 2000991 | ||||||
DOI: | 10.1002/mnfr.202000991 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 14 July 2021 | ||||||
Date of first compliant Open Access: | 14 July 2021 | ||||||
RIOXX Funder/Project Grant: |
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