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Extensive cortical connectivity of the human hippocampal memory system : beyond the “what” and “where” dual stream model
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Huang, Chu-Chung, Rolls, Edmund T., Hsu, Chih-Chin Heather, Feng, Jianfeng and Lin, Ching-Po (2021) Extensive cortical connectivity of the human hippocampal memory system : beyond the “what” and “where” dual stream model. Cerebral Cortex, 31 (10). pp. 4652-4669. doi:10.1093/cercor/bhab113 ISSN 1460-2199.
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WRAP-Extensive-cortical-connectivity-human-hippocampal-memory-system-2021.pdf - Accepted Version - Requires a PDF viewer. Download (1530Kb) | Preview |
Official URL: https://doi.org/10.1093/cercor/bhab113
Abstract
The human hippocampus is involved in forming new memories: damage impairs memory. The dual stream model suggests that object “what” representations from ventral stream temporal cortex project to the hippocampus via the perirhinal and then lateral entorhinal cortex, and spatial “where” representations from the dorsal parietal stream via the parahippocampal gyrus and then medial entorhinal cortex. The hippocampus can then associate these inputs to form episodic memories of what happened where. Diffusion tractography was used to reveal the direct connections of hippocampal system areas in humans. This provides evidence that the human hippocampus has extensive direct cortical connections, with connections that bypass the entorhinal cortex to connect with the perirhinal and parahippocampal cortex, with the temporal pole, with the posterior and retrosplenial cingulate cortex, and even with early sensory cortical areas. The connections are less hierarchical and segregated than in the dual stream model. This provides a foundation for a conceptualization for how the hippocampal memory system connects with the cerebral cortex and operates in humans. One implication is that prehippocampal cortical areas such as the parahippocampal TF and TH subregions and perirhinal cortices may implement specialized computations that can benefit from inputs from the dorsal and ventral streams.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QM Human anatomy | |||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Hippocampus (Brain), Hippocampus (Brain) -- Blood-vessels, Episodic memory | |||||||||||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex | |||||||||||||||||||||||||||
Publisher: | Oxford University Press (OUP) | |||||||||||||||||||||||||||
ISSN: | 1460-2199 | |||||||||||||||||||||||||||
Official Date: | October 2021 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 31 | |||||||||||||||||||||||||||
Number: | 10 | |||||||||||||||||||||||||||
Page Range: | pp. 4652-4669 | |||||||||||||||||||||||||||
DOI: | 10.1093/cercor/bhab113 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication Chu-Chung Huang, Edmund T Rolls, Chih-Chin Heather Hsu, Jianfeng Feng, Ching-Po Lin, Extensive Cortical Connectivity of the Human Hippocampal Memory System: Beyond the “What” and “Where” Dual Stream Model, Cerebral Cortex, 2021;, bhab113, https://doi.org/10.1093/cercor/bhab113 following peer review. The version of record is available online at: https://doi.org/10.1093/cercor/bhab113 | |||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||
Copyright Holders: | © The Author(s) 2021. Published by Oxford University Press. All rights reserved | |||||||||||||||||||||||||||
Date of first compliant deposit: | 9 June 2021 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 19 May 2022 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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