UNSPECIFIED (1998) The specification of the pronephric tubules and duct in Xenopus laevis. MECHANISMS OF DEVELOPMENT, 75 (1-2). pp. 127-137. ISSN 0925-4773

Full text not available from this repository.

Abstract

We have examined the timing of specification of the pronephric tubules and duct in Xenopus laevis by explanting the presumptive pronephric rudiments into blastula ectodermal wraps. We have established I-he time point of specification using the monoclonal antibody markers 3G8 and 4A6 which recognize antigens in pronephric tubule and duct, respectively. We show that, by experimental analysis in explants, kidney tubules are specified by stage 12.5 in the pronephric anlagen whereas pronephric duct is specified later between stages 13 and 14. Furthermore we show that signals involved in tubulogenesis of the pronephric tubules are normally received between stage 12.5 and 13. These experiments unambiguously pinpoint the timing of pronephros specification analyzed by explant experimentation to a developmental stage prior to that demonstrated for urodele amphibia, and provide an essential biological backdrop to a search for the molecular nature of pronephric inducers. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	MECHANISMS OF DEVELOPMENT
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0925-4773
Date:	July 1998
Volume:	75
Number:	1-2
Number of Pages:	11
Page Range:	pp. 127-137
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/15340

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item